Evidence map›Paper›PMID 33756104›Full record

ArticleNeuron2021

Single-trial decoding of movement intentions using functional ultrasound neuroimaging.

Sumner L Norman, David Maresca, Vassilios N Christopoulos, Whitney S Griggs, Charlie Demene, Mickael Tanter, Mikhail G Shapiro, Richard A Andersen

Abstract read
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
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  11. Exploring Neural Dynamics in the Auditory Telencephalon of Crows Using Functional Ultrasound Imaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Article
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  16. Review
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  20. Non-Invasive Brain-Computer Interfaces: State of the Art and Trends.IEEE reviews in biomedical engineering · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sumner L NormanBiology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
David MarescaChemistry & Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Vassilios N ChristopoulosBiology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; T&C Chen Brain-Machine Interface Center, California Institute of Technology, Pasadena, CA 91125, USA.
Whitney S GriggsBiology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Charlie DemenePhysics for Medicine Paris, INSERM, CNRS, ESPCI Paris, PSL Research University, 75012 Paris, France; INSERM Technology Research Accelerator in Biomedical Ultrasound, Paris, France.
Mickael TanterPhysics for Medicine Paris, INSERM, CNRS, ESPCI Paris, PSL Research University, 75012 Paris, France; INSERM Technology Research Accelerator in Biomedical Ultrasound, Paris, France.
Mikhail G ShapiroChemistry & Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: mikhail@caltech.edu.
Richard A AndersenBiology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; T&C Chen Brain-Machine Interface Center, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: richard.andersen@vis.caltech.edu.

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Minimally Invasive Ultrasonic Brain-Machine InterfaceR01NS123663 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANDERSEN, RICHARD A, SHAPIRO, MIKHAIL · 2021 to 2021
$3.3M
Molecular Functional Ultrasound for Non-Invasive Imaging and Image-Guided Recording and Modulation of Neural ActivityU01NS099724 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI SHAPIRO, MIKHAIL · 2016 to 2018
$2.1M
NIGMS NIH HHS T32 GM008042NINDS NIH HHS R01 NS123663NINDS NIH HHS U01 NS099724
6 · The paper itself

Abstract

New technologies are key to understanding the dynamic activity of neural circuits and systems in the brain. Here, we show that a minimally invasive approach based on ultrasound can be used to detect the neural correlates of movement planning, including directions and effectors. While non-human primates (NHPs) performed memory-guided movements, we used functional ultrasound (fUS) neuroimaging to record changes in cerebral blood volume with 100 μm resolution. We recorded from outside the dura above the posterior parietal cortex, a brain area important for spatial perception, multisensory integration, and movement planning. We then used fUS signals from the delay period before movement to decode the animals' intended direction and effector. Single-trial decoding is a prerequisite to brain-machine interfaces, a key application that could benefit from this technology. These results are a critical step in the development of neuro-recording and brain interface tools that are less invasive, high resolution, and scalable.

Indexed as

IntentionAnimalsBrain-Computer InterfacesBrain MappingMacaca mulattaMaleMovementNeuroimagingParietal LobePsychomotor PerformanceUltrasonographyBrain-machine interfacefunctional ultrasound neuroimagingmovement planningNon-human primatePosterior parietal CortexReachSaccadesingle-trial decoding

Identifiers

PMID33756104
PMCPMC8105283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.