Evidence map›Paper›PMID 33756049›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

COVID-19 mortality among kidney transplant candidates is strongly associated with social determinants of health.

Jesse D Schold, Kristen L King, S Ali Husain, Emilio D Poggio, Laura D Buccini, Sumit Mohan

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Impact of Social Determinants of Health in Spine Surgery.Current reviews in musculoskeletal medicine · 2023
    Review
  8. Article
  9. Utilization and outcomes of deceased donor SARS-CoV-2-positive organs for solid organ transplantation in the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  10. Article
  11. Changing trends in mortality among solid organ transplant recipients hospitalized for COVID-19 during the course of the pandemic.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  12. Article
  13. COVID-19-Associated Mortality among Kidney Transplant Recipients and Candidates in the United States.Clinical journal of the American Society of Nephrology : CJASN · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jesse D ScholdDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0002-5341-7286
Kristen L KingDivision of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.ORCID 0000-0002-7920-7615
S Ali HusainDivision of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.ORCID 0000-0002-1823-0117
Emilio D PoggioGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0003-1492-5103
Laura D BucciniCenter for Populations Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Sumit MohanDivision of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.ORCID 0000-0002-5305-9685

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
National Science Foundation 2032726NCATS NIH HHS UL1 TR002548
6 · The paper itself

Abstract

The COVID-19 pandemic has affected all portions of the global population. However, many factors have been shown to be particularly associated with COVID-19 mortality including demographic characteristics, behavior, comorbidities, and social conditions. Kidney transplant candidates may be particularly vulnerable to COVID-19 as many are dialysis-dependent and have comorbid conditions. We examined factors associated with COVID-19 mortality among kidney transplant candidates from the National Scientific Registry of Transplant Recipients from March 1 to December 1, 2020. We evaluated crude rates and multivariable incident rate ratios (IRR) of COVID-19 mortality. There were 131 659 candidates during the study period with 3534 all-cause deaths and 384 denoted a COVID-19 cause (5.00/1000 person years). Factors associated with increased COVID-19 mortality included increased age, males, higher body mass index, and diabetes. In addition, Blacks (IRR = 1.96, 95% C.I.: 1.43-2.69) and Hispanics (IRR = 3.38, 95% C.I.: 2.46-4.66) had higher COVID-19 mortality relative to Whites. Patients with lower educational attainment, high school or less (IRR = 1.93, 95% C.I.: 1.19-3.12, relative to post-graduate), Medicaid insurance (IRR = 1.73, 95% C.I.: 1.26-2.39, relative to private), residence in most distressed neighborhoods (fifth quintile IRR = 1.93, 95% C.I.: 1.28-2.90, relative to first quintile), and most urban and most rural had higher adjusted rates of COVID-19 mortality. Among kidney transplant candidates in the United States, social determinants of health in addition to demographic and clinical factors are significantly associated with COVID-19 mortality.

Indexed as

COVID-19Kidney TransplantationHumansMalePandemicsSARS-CoV-2Social Determinants of HealthUnited Statesclinical research/practiceethnicity/racehealth services and outcomes researchinfection and infectious agentskidney diseasekidney transplantation/nephrologyorgan transplantation in generalrisk assessment/risk stratificationwaitlist management

Identifiers

PMID33756049
PMCPMC8250928

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.