Evidence map›Paper›PMID 33755931›Full record

ArticleJournal of nephrology2021

Association between the transtubular potassium gradient and progression of chronic kidney disease: results from KNOW-CKD.

Seon Yeong Lee, Jung Tak Park, Young Su Joo, Tae-Hyun Yoo, Joongyub Lee, Wookyung Chung, Yong-Soo Kim, Soo Wan Kim, Kook-Hwan Oh, Curie Ahn and 3 more

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Article in Journal of nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Seon Yeong LeeDepartment of Internal Medicine, Institute of Kidney Disease Research, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Jung Tak ParkDepartment of Internal Medicine, Institute of Kidney Disease Research, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Young Su JooDivision of Nephrology, Department of Internal Medicine, Myongji Hospital, Goyang, Republic of Korea.
Tae-Hyun YooDepartment of Internal Medicine, Institute of Kidney Disease Research, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Joongyub LeeDepartment of Prevention and Management, Inha University School of Medicine, Incheon, Republic of Korea.
Wookyung ChungDepartment of Internal Medicine, Gil Hospital, Gachon University, Incheon, South Korea.
Yong-Soo KimDepartment of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
Soo Wan KimDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Kook-Hwan OhDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Curie AhnDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Shin-Wook KangDepartment of Internal Medicine, Institute of Kidney Disease Research, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Kyu Hun ChoiDepartment of Internal Medicine, Institute of Kidney Disease Research, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Seung Hyeok HanDepartment of Internal Medicine, Institute of Kidney Disease Research, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. hansh@yuhs.ac.ORCID http://orcid.org/0000-0001-7923-5635
Yonsei University · KRSeoul National University · KRChonnam National University · KRDeleted InstitutionInha University · KRMyongji Hospital · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KR

Funding

Korea Centers for Disease Control and Prevention 2011E3300300Korea Centers for Disease Control and Prevention 2012E3301100Korea Centers for Disease Control and Prevention 2013E3301600Korea Centers for Disease Control and Prevention 2013E3301601Korea Centers for Disease Control and Prevention 2013E3301602Korea Centers for Disease Control and Prevention 2016E3300200Korea Centers for Disease Control and Prevention 2016E3300201Korea Centers for Disease Control and Prevention 2016E3300202Korea Centers for Disease Control and Prevention 2019E320100Korea Centers for Disease Control and Prevention 2019E320101
6 · The paper itself

Abstract

backgroundThe transtubular potassium gradient which reflects potassium secretion by the kidney through the cortical collecting duct, has not yet been tested as a surrogate marker of kidney function decline. Here, we investigate the relationship between the transtubular potassium gradient and chronic kidney disease (CKD) progression.

methodsWe studied 1672 patients from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort. The transtubular potassium gradient was calculated using a standard equation. The study endpoint was CKD progression, defined as a composite of a ≥ 50% decrease in estimated glomerular filtration rate (eGFR) from baseline values or end-stage kidney disease.

resultsDuring a median follow-up of 4.1 years (7149 person-years), 441 participants reached the endpoint. In cause-specific competing risk analysis, the highest tertile was associated with a significantly lower risk of an adverse kidney outcome compared with the lowest tertile [hazard ratio (HR), 0.73; 95% confidence interval (CI), 0.55-0.97]. When the transtubular potassium gradient was treated as a continuous variable, an increase of 1 in the transtubular potassium gradient was associated with a 6% lower risk of CKD progression (95% CI, 0.90-0.99). This association was particularly evident in patients with an eGFR ≥ 45 mL/min/1.73 m

conclusionsA higher transtubular potassium gradient is associated with a significantly lower risk of CKD progression, suggesting that it may offer insights into the prognosis of CKD.

Indexed as

Renal Insufficiency, ChronicCohort StudiesDisease ProgressionGlomerular Filtration RateHumansPotassiumProspective StudiesRisk FactorsPotassiumCKD progressionTranstubular potassium gradient (TTKG)Urinary potassium excretion

Identifiers

PMID33755931
OpenAlexW3137076382

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.