Evidence map›Paper›PMID 33755785›Full record

ReviewBasic research in cardiology2021

Adenosine and adenosine receptor-mediated action in coronary microcirculation.

Ying Zhang, Bernhard Wernly, Xin Cao, S Jamal Mustafa, Yong Tang, Zhichao Zhou

Open access · hybridAbstract readReview
In one paragraph

Review in Basic research in cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Applying Deep-Learning-DrivenJournal of medicinal chemistry · 2026
    Article
  4. Review
  5. Betaine Alters the Interplay of the Adenosine andInternational journal of molecular sciences · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
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  17. Review
  18. Review
  19. Article
  20. Endothelial dysfunction in chronic kidney disease: a clinical perspective.American journal of physiology. Heart and circulatory physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Ying ZhangThe International Collaborative Centre On Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Bernhard WernlyDepartment of Anaesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University of Salzburg, Salzburg, Austria.
Xin CaoThe International Collaborative Centre On Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
S Jamal MustafaDepartment of Physiology and Pharmacology, West Virginia University, Morgantown, USA.
Yong TangThe International Collaborative Centre On Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhichao ZhouDivision of Cardiology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 17176, Stockholm, Sweden. zhichao.zhou@ki.se.ORCID http://orcid.org/0000-0002-5107-6529
Chengdu University of Traditional Chinese Medicine · CNKarolinska University Hospital · SEUniversity of Salzburg · ATWest Virginia University · US

Funding

Hjärt-Lungfonden 20190341 and 20200326Loo och Hans Ostermans Stiftelse för Medicinsk Forskning 2018-01213Loo och Hans Ostermans Stiftelse för Medicinsk Forskning 2020-01209National Natural Science Foundation of China 81904306)Stiftelsen Lars Hiertas Minne FO2018-0156the National Key R&D Program of China 2019YFC1709101the Project First-Class Disciplines Development of Chengdu University of Traditional Chinese Medicine CZYHW1901the Science and Technology Program of Sichuan Province 20GJHZ0036
6 · The paper itself

Abstract

Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in the regulation of coronary microcirculation through activation of adenosine receptors (ARs). Adenosine is regulated by various enzymes and nucleoside transporters for its balance between intra- and extracellular compartments. Adenosine-mediated coronary microvascular tone and reactive hyperemia are through receptors mainly involving A

Indexed as

Coronary CirculationHemodynamicsMicrocirculationAdenosineAnimalsCardiovascular DiseasesCoronary VesselsHumansMicrovesselsPotassium ChannelsReceptors, Purinergic P1Signal TransductionAdenosinePotassium ChannelsReceptors, Purinergic P1AdenosineCoronary microcirculationDiabetesExtracellular nucleotidesIschemic heart diseasePurinergic receptor

Identifiers

PMID33755785
PMCPMC7987637
OpenAlexW3136355169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.