SynthesisPediatric radiology2021
Diagnostic accuracy of two-dimensional shear wave elastography in detecting hepatic fibrosis in children with autoimmune hepatitis, biliary atresia and other chronic liver diseases.
Synthesis in Pediatric radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Performance of two-dimensional shear wave elastography for detecting advanced liver fibrosis and cirrhosis in patients with biliary atresia: a systematic review and meta-analysis.Pediatric radiology · 2023Pooled it
- Fontan-associated liver disease: The role of liver elastography assessments pre- and post-heart transplant.Journal of pediatric gastroenterology and nutrition · 2026Article
- Spleen and liver shear wave elastography for assessment of portal hypertension in children with biliary atresia.Scientific reports · 2026Article
- Evaluation of Ultrasound-Based Parameters for the Assessment of Hepatic Steatosis and Fibrosis in Hungarian Wilson's Disease Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Performance of Blood-Based Indirect Scores Compared to Transient Elastography in Children with Chronic Liver Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Matrix stiffness may drive multi-cellular crosstalk via YAP signaling in biliary atresia liver fibrosis: a mechanistic review.Frontiers in cell and developmental biology · 2026Review
- Identification of abdominal MRI features associated with histopathological severity and treatment response in autoimmune hepatitis.European radiology · 2025Article
- Unmet needs in autoimmune liver diseases.Current opinion in immunology · 2025Review
- Ultrasound innovations in abdominal radiology: techniques and clinical applications in pediatric imaging.Abdominal radiology (New York) · 2025Review
- Assessment of the utility of two-dimensional shear wave elastography and superb microvascular imaging in postoperative patients with biliary atresia.Pediatric surgery international · 2024Article
- Natural Products in Liver Fibrosis Management: A Five-year Review.Current medicinal chemistry · 2024Review
- Combi-Elasto Evaluation of the Degree of Liver Fibrosis in Children with Cholestatic Liver Disease.Diagnostics (Basel, Switzerland) · 2023Article
- Ultrasound Elastography in Children.Children (Basel, Switzerland) · 2023Review
- Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation.Ultrasonography (Seoul, Korea) · 2023Article
- Autoimmune Hepatitis and Fibrosis.Journal of clinical medicine · 2023Review
- Liver fibrosis in children: a comprehensive review of mechanisms, diagnosis, and therapy.Clinical and experimental pediatrics · 2023Article
- A novel prediction tool based on shear wave elastography, gallbladder ultrasound, and serum biomarkers for the early diagnosis of biliary atresia in infants younger than 60 days old.Quantitative imaging in medicine and surgery · 2023Article
- Article
- Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2022Review
- Ultrasound elastography in children - nice to have for scientific studies or arrived in clinical routine?Molecular and cellular pediatrics · 2022Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough fibrosis is the main determinant of liver stiffness, other disease-related factors usually disregarded in studies on liver elastography, such as inflammation and cholestasis, may influence liver stiffness.
objectiveTo evaluate the accuracy of two-dimensional (2-D) shear wave elastography in assessing liver fibrosis in children with chronic liver disease by controlling for the confounding role of several disease- and patient-related factors. MATERIALS AND
methodsThree disease groups were studied: 1) various chronic liver diseases, 2) autoimmune hepatitis and 3) biliary atresia. The METAVIR (meta-analysis of histological data in viral hepatitis) score was used for fibrosis staging and grading of necroinflammatory activity. Multiple linear regression was used to evaluate the relationship between liver stiffness measurements and disease-related factors. The diagnostic accuracy of elastography for predicting fibrosis stages was assessed by calculating the area under the receiver operating characteristic curves.
resultsThe various chronic liver diseases group (n=32; 7.1±4.9 [mean±standard deviation] years) showed liver stiffness of 8.9±5.0 (mean±standard deviation) kPa, the autoimmune hepatitis group (n=33; 8.1±4.4 years) of 7.1±2.7 kPa, and the biliary atresia group (n=19; 0.2±0.1 years) of 19.7±15.2 kPa. Liver stiffness measurements differed across METAVIR fibrosis categories in all disease groups. The highest values were found in biliary atresia, at fibrosis stages ≥F2 (F2: 12.4±1.6 kPa, F3: 17.8±2 kPa, F4: 41.5±12.4 kPa). Liver stiffness was strongly associated only with fibrosis (P<0.0001) in various chronic liver diseases, but with necroinflammatory activity (P<0.0001) and fibrosis (P=0.002) in autoimmune hepatitis, and with age (P<0.0001), fibrosis (P<0.0001) and cholestasis (P=0.009) in biliary atresia. Optimal cutoffs for detecting advanced fibrosis (≥F3) were 16 kPa (area under curve: 0.98; sensitivity: 87.5%; specificity: 96.7%) in biliary atresia and 8.7 kPa (area under curve: 0.98; sensitivity: 93.8%; specificity: 96.1%) in other chronic liver diseases.
conclusionTwo-dimensional shear wave elastography is reliable in assessing liver fibrosis in children with chronic liver diseases.
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