Evidence map›Paper›PMID 33755455›Full record

ArticleThe Journal of organic chemistry2021

Properties of a "Split-and-Stuttering" Module of an Assembly Line Polyketide Synthase.

Katarina M Guzman, Kai P Yuet, Stephen R Lynch, Corey W Liu, Chaitan Khosla

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katarina M Guzman
Kai P Yuet
Stephen R Lynch
Corey W Liu

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
Proposal for Central California 900 MHZ NMR SpectrometerP41GM068933 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI WEMMER, DAVID E · 2003 to 2007
$5.9M
Structure, Mechanism, and Engineering of Assembly Line Polyketide SynthasesR01GM087934 · NIGMS · STANFORD UNIVERSITY · PI KHOSLA, CHAITAN · 2009 to 2021
$4.9M
Analysis of Nocardia Assembly-Line Polyketide Synthases and Their Role in NocardiosisF32GM123637 · NIGMS · STANFORD UNIVERSITY · PI YUET, KAI P. · 2017 to 2019
$177k
NCI NIH HHS P30 CA124435NIGMS NIH HHS F32 GM123637NIGMS NIH HHS P41 GM068933NIGMS NIH HHS R01 GM087934
6 · The paper itself

Abstract

Notwithstanding the "one-module-one-elongation-cycle" paradigm of assembly line polyketide synthases (PKSs), some PKSs harbor modules that iteratively elongate their substrates through a defined number of cycles. While some insights into module iteration, also referred to as "stuttering", have been derived through

Indexed as

Escherichia coli ProteinsPolyketidesStutteringBacterial Outer Membrane ProteinsEscherichia coliHumansPolyketide SynthasesBacterial Outer Membrane ProteinsEscherichia coli ProteinsPolyketidesPolyketide SynthasestraN protein, E coli

Identifiers

PMID33755455
PMCPMC8380650

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.