ArticleESC heart failure2021
The effect of high-flow arteriovenous fistulas on systemic haemodynamics and brain oxygenation.
Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Dialysis-associated muscle cramps related to high-flow arteriovenous fistula and high cardiac output failure reversed with fistula ligation.Clinical kidney journal · 2026Review
- Ultrasonic diagnosis of congenital descending aortapulmonary vein fistula: a case description.Quantitative imaging in medicine and surgery · 2026Article
- How to Define High-Flow Arteriovenous Fistula? Comment on Kim et al. Hemodynamic Adaptation and Cardiac Effects of High-Flow Arteriovenous Access in Hemodialysis Patients: A Prospective Study.Journal of clinical medicine · 2025Article
- Review
- Right ventricular-pulmonary arterial coupling and pulmonary hypertension in hemodialysis: insights into structural cardiac changes and clinical implications.Renal failure · 2025Article
- Vascular Access for Hemodialysis and Right Ventricular Remodeling: A Prospective Echocardiographic Study.Journal of clinical medicine · 2025Article
- Hemodynamic Adaptation and Cardiac Effects of High-Flow Arteriovenous Access in Hemodialysis Patients: A Prospective Study.Journal of clinical medicine · 2025Article
- Beyond the vascular access: unveiling the cardiovascular impact of dialysis access flow rates.Journal of cardiothoracic surgery · 2025Observational
- Clinical influencing factors affecting pulmonary hypertension in hemodialysis patients.Kidney research and clinical practice · 2025Article
- Vascular Access Management After Kidney Transplantation Position Paper on Behalf of the Vascular Access Society and the European Kidney Transplant Association.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Non-invasively assessed haemodynamics in patients with high flow arteriovenous fistula and high output cardiac failure.ESC heart failure · 2024Article
- Reply to: 'Non-invasively assessed hemodynamics in patients with high flow arteriovenous fistula and high output cardiac failure'.ESC heart failure · 2024Article
- Hemodialysis Patients with High-Flow Arteriovenous Fistulas: An Evaluation of the Impact on Cardiac Function.Vascular specialist international · 2024Article
- Systemic vascular resistance predicts high-output cardiac failure in patients with high-flow arteriovenous fistula.ESC heart failure · 2024Article
- Management of Arteriovenous Fistula After Successful Kidney Transplantation in Long-Term Follow-Up.Transplant international : official journal of the European Society for Organ Transplantation · 2024Observational
- An ultrasound-guided no incision banding method for the treatment of arteriovenous fistula high-flow in hemodialysis.Renal failure · 2023Article
- Effects of percutaneous transluminal angioplasty and associated factors in access hand oxygenation in patients undergoing hemodialysis.Scientific reports · 2023Article
- Comparing the hemodynamic effect of a large arteriovenous fistula during high and low cardiac output states.Frontiers in physiology · 2023Article
- A large arteriovenous fistula steals a considerable part of systemic blood flow during veno-arterial extracorporeal circulation support in a porcine model.Frontiers in physiology · 2023Article
- Heart failure with preserved ejection fraction is the most frequent but commonly overlooked phenotype in patients on chronic hemodialysis.Frontiers in cardiovascular medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsHigh-flow arteriovenous fistula (AVF) for haemodialysis leads to profound haemodynamic changes and sometimes to heart failure (HF). Cardiac output (CO) is divided between the AVF and body tissues. The term effective CO (COef) represents the difference between CO and AVF flow volume (Qa) and better characterizes the altered haemodynamics that may result in organ hypoxia. We investigated the effects of Qa reduction on systemic haemodynamics and on brain oxygenation. METHODS AND
resultsThis is a single-centre interventional study. Twenty-six patients on chronic haemodialysis with high Qa (>1500 mL/min) were indicated for surgical Qa reduction for HF symptoms and/or signs of structural heart disease on echocardiography. The included patients underwent three sets of examinations: at 4 months and then 2 days prior and 6 weeks post-surgical procedure. Clinical status, echocardiographical haemodynamic assessment, Qa, and brain oximetry were recorded. All parameters remained stable from selection to inclusion. After the procedure, Qa decreased from 3.0 ± 1.4 to 1.3 ± 0.5 L/min, P < 0.00001, CO from 7.8 ± 1.9 to 6.6 ± 1.5 L/min, P = 0.0002, but COef increased from 4.6 ± 1.4 to 5.3 ± 1.4 L/min, P = 0.036. Brain tissue oxygen saturation increased from 56 ± 11% to 60 ± 9%, P = 0.001.
conclusionsQa reduction led to increased COef. This was explained by a decreased proportion of CO running through the AVF in patients with Qa > 2.0 L/min. These observations were mirrored by higher brain oxygenation and might explain HF symptoms and improved haemodynamics even in asymptomatic high Qa patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.