Evidence map›Paper›PMID 33755337›Full record

ArticleChemMedChem2021

An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation.

Anna R Kaplan, Cassandra L Schrank, William M Wuest

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Enantioselective Total Synthesis of Two Aromatized Halicyclamines.Journal of the American Chemical Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anna R KaplanChemistry Department, Emory University, Atlanta, GA 30322, USA.
Cassandra L SchrankChemistry Department, Emory University, Atlanta, GA 30322, USA.
William M WuestChemistry Department, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-5198-7744

Funding

Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026
$4.8M
Antimicrobial Resistance and Therapeutic Discovery Training ProgramT32AI106699 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Joanna B Goldberg · 2014 to 2026
$2.7M
NIAID NIH HHS T32 AI106699NIGMS NIH HHS R35 GM119426NIH HHS CHE1531620
6 · The paper itself

Abstract

3-Alkylpyridine alkaloids (3-APAs) isolated from the arctic sponge Haliclona viscosa are a promising group of bioactive marine alkaloids. However, due to limited bioavailability, investigations of their bioactivity have been hampered. Additionally, synthesis of a common intermediate requires the use of protecting groups and harsh conditions. In this work, we developed a simple and concise two-step route to nine different natural and synthetic haliclocyclins. These compounds displayed modest antibiotic activity against several Gram-positive bacterial strains.

Indexed as

AlkaloidsAnti-Bacterial AgentsDose-Response Relationship, DrugGram-Positive BacteriaMicrobial Sensitivity TestsMolecular ConformationPyridinesStructure-Activity RelationshipAlkaloidsAnti-Bacterial AgentsPyridinesantimicrobialhaliclocyclinshydroarylationMRSAquaternary ammonium compounds

Identifiers

PMID33755337
PMCPMC8895759

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.