ArticleMagnetic resonance in medicine2021
Superoxide free radical spin-lattice relaxivity: A quench-assisted MR study.
Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- MRI of radiation chemistry: First images and investigation of potential mechanisms.Medical physics · 2023Article
- Superoxide free radical spin-lattice relaxivity: A quench-assisted MR study.Magnetic resonance in medicine · 2021Article
- Correcting QUEST Magnetic Resonance Imaging-Sensitive Free Radical Production in the Outer Retina In Vivo Does Not Correct Reduced Visual Performance in 24-Month-Old C57BL/6J Mice.Investigative ophthalmology & visual science · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeQuEnch-assiSTed (QUEST) MRI provides a unique biomarker of excessive production of paramagnetic free radicals (oxidative stress) in vivo. The contribution from superoxide, a common upstream species found in oxidative stress-based disease, to the QUEST metric is unclear. Here, we begin to address this question by measuring superoxide spin-lattice relaxivity (r1) in phantoms.
methodsStable superoxide free radicals were generated in water phantoms of potassium superoxide (
resultsThe T
conclusionOur first-in-kind measurement of superoxide free radical r1 suggests a detection sensitivity of QUEST MRI on the order of tens of μM, within the reported level of free radical production during oxidative stress in vivo. Similar studies for other common free radicals are needed.
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Registered trials
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