Trial reportSleep2021
Sleep-dependent prospective memory consolidation is impaired with aging.
Trial report in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Comorbid insomnia and sleep apnea is associated with worse verbal episodic memory in older females.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Trial
- Feasibility and Acceptability of a Remote Sleep-Dependent Memory Assessment in Older Adults With Cognitive Concerns: Pilot Cross-Sectional Study.JMIR aging · 2026Article
- The Status and Associated Factors of Prospective Memory among Iranian Older Adults.Current aging science · 2026Article
- Sleep Across the Lifespan: A Neurobehavioral Perspective.Current sleep medicine reports · 2025Review
- Associations between longitudinal changes in sleep stages and risk of cognitive decline in older men.Sleep · 2024Article
- Slow wave activity disruptions and memory impairments in a mouse model of aging.Neurobiology of aging · 2024Article
- Review
- Sleep preferentially consolidates negative aspects of human memory: Well-powered evidence from two large online experiments.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sleep-dependent memory consolidation in breast cancer: Use of a virtual reality prospective memory task.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesExisting literature suggests that sleep-dependent memory consolidation is impaired in older adults but may be preserved for personally relevant information. Prospective memory (PM) involves remembering to execute future intentions in a timely manner and has behavioral importance. As previous work suggests that N3 sleep is important for PM in young adults, we investigated if the role of N3 sleep in PM consolidation would be maintained in older adults.
methodsForty-nine young adults (mean age ± SD: 21.8 ± 1.61 years) and 49 healthy older adults (mean age ± SD: 65.7 ± 6.30 years) were randomized into sleep and wake groups. After a semantic categorization task, participants encoded intentions comprising four related and four unrelated cue-action pairs. They were instructed to remember to perform these actions in response to cue words presented during a second semantic categorization task 12 h later that encompassed either daytime wake (09:00 am-21:00 pm) or overnight sleep with polysomnography (21:00 pm-09:00 am).
resultsThe significant condition × age group × relatedness interaction suggested that the sleep benefit on PM intentions varied according to age group and relatedness (p = 0.01). For related intentions, sleep relative to wake benefitted young adults' performance (p < 0.001) but not older adults (p = 0.30). For unrelated intentions, sleep did not improve PM for either age group. While post-encoding N3 was significantly associated with related intentions' execution in young adults (r = 0.43, p = 0.02), this relationship was not found for older adults (r = -0.07, p = 0.763).
conclusionsThe age-related impairment of sleep-dependent memory consolidation extends to PM. Our findings add to an existing body of work suggesting that the link between sleep and memory is functionally weakened in older adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.