ArticleThe Journal of clinical endocrinology and metabolism2021
Causal Association Between Serum Thyrotropin and Obesity: A Bidirectional, Mendelian Randomization Study.
Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- A systematic review and meta-analysis investigating the relationship between metabolic syndrome and the incidence of thyroid diseases.Endocrine · 2024Pooled it
- Type 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study.Scientific reports · 2024Pooled it
- Article
- Obesity-related thyroid reflections: from weight gain to weight loss.European thyroid journal · 2026Review
- Article
- Overnutrition in mice impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations.The Journal of clinical investigation · 2026Article
- Diet's rapid effects on the thyroid gland challenge unidirectional assumptions about hypothyroidism and energy balance.The Journal of clinical investigation · 2026Article
- The public health burden of diabetes mellitus and thyroid disease: twin epidemics.Nature reviews. Endocrinology · 2026Review
- Association of high-normal thyroid-stimulating hormone levels with metabolic syndrome and abdominal obesity in euthyroid adolescents: insights from the Korea National Health and Nutrition Examination Survey.Annals of pediatric endocrinology & metabolism · 2025Article
- Independent Effects of Hypothyroidism and Obesity on Endometrial Cancer Risk Revealed by Mendelian Randomisation.Biomedicines · 2025Article
- The role of preeclampsia in breast cancer risk: insights from Mendelian randomization study.Discover oncology · 2025Article
- Deciphering genetic causality between plasma BDNF and 91 circulating inflammatory proteins through bidirectional mendelian randomization.Scientific reports · 2025Article
- Free triiodothyronine and risk of gestational diabetes mellitus: an observational study and Mendelian randomization analysis.Nutrition & metabolism · 2025Article
- Associations of thyroid feedback quantile-based index with diabetes in euthyroid adults in the United States and China.Annals of medicine · 2024Article
- Relationship between thyroid-stimulating hormone and blood lipids in patients with first-episode depression.BMC psychiatry · 2024Article
- GLP-1 Receptor Agonists: A Promising Therapy for Modern Lifestyle Diseases with Unforeseen Challenges.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Association between the triglyceride-glucose index and thyroid disorders: a cross-sectional survey and Mendelian randomization analysis.Endocrine · 2024Article
- Thyroid function, physical activity and sedentary behaviour: A bidirectional two-sample Mendelian randomisation study.Journal of global health · 2024Article
- Implications of GLP-1 Receptor Agonist on Thyroid Function: A Literature Review of Its Effects on Thyroid Volume, Risk of Cancer, Functionality and TSH Levels.Biomolecules · 2024Review
- Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?Current nutrition reports · 2024Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe association between serum thyrotropin (TSH) and obesity traits has been investigated previously in several epidemiological studies. However, the underlying causal association has not been established.
objectiveThis work aimed to determine and analyze the causal association between serum TSH level and obesity-related traits (body mass index [BMI] and obesity).
methodsThe latest genome-wide association studies (GWASs) on TSH, BMI, and obesity were searched to obtain full statistics. Bidirectional 2-sample mendelian randomization (MR) was performed to explore the causal relationship between serum TSH and BMI and obesity. The inverse variance-weighted (IVW) and MR-Egger methods were used to combine the estimation for each single-nucleotide variation (formerly single-nucleotide polymorphism). Based on the preliminary MR results, free thyroxine (fT4) and free 3,5,3'-triiodothyronine (fT3) levels were also set as outcomes to further analyze the impact of BMI on them. BMI and obesity were treated as the outcomes to evaluate the effect of serum TSH on them, and TSH was set as the outcome to estimate the effect of BMI and obesity on it.
resultsIVW and MR-Egger results both indicated that genetically driven serum TSH did not causally lead to changes in BMI or obesity. Moreover, the IVW method showed that the TSH level could be significantly elevated by genetically predicted high BMI (β = .038, SE = 0.013, P = .004). In further MR analysis, the IVW method indicated that BMI could causally increase the fT3 (β = 10.123, SE = 2.523, P < .001) while not significantly affecting the fT4 level.
conclusionTogether with fT3, TSH can be significantly elevated by an increase in genetically driven BMI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.