ArticleEnvironmental microbiology2021
C4-dicarboxylates and l-aspartate utilization by Escherichia coli K-12 in the mouse intestine: l-aspartate as a major substrate for fumarate respiration and as a nitrogen source.
Article in Environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
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- Interplay between chemotaxis, quorum sensing, and metabolism regulates Escherichia coli-Salmonella Typhimurium interactions in vivo.PLoS pathogens · 2025Article
- Molecules-mediated bidirectional interactions between microbes and human cells.NPJ biofilms and microbiomes · 2025Review
- Monosaccharides drive Salmonella gut colonization in a context-dependent or -independent manner.Nature communications · 2025Article
- Nutrition ofEcoSal Plus · 2024Review
- Aspartate aminotransferase ofMicrobiology (Reading, England) · 2024Article
- Salmonella Typhimurium expansion in the inflamed murine gut is dependent on aspartate derived from ROS-mediated microbiota lysis.Cell host & microbe · 2024Article
- Nitrogen assimilation bymBio · 2024Article
- The protein carboxymethyltransferase-dependent aspartate salvage pathway plays a crucial role in the intricate metabolic network ofScience advances · 2024Article
- Systematic review of metabolomic alterations in ulcerative colitis: unveiling key metabolic signatures and pathways.Therapeutic advances in gastroenterology · 2024Review
- Enterohaemorrhagic E. coli utilizes host- and microbiota-derived L-malate as a signaling molecule for intestinal colonization.Nature communications · 2023Article
- Asuc_0142 ofMicrobiology (Reading, England) · 2023Article
- Article
- Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn's disease.JCI insight · 2022Article
- CJournal of bacteriology · 2022Review
- Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensaleLife · 2021Article
- Aspartate in the intestine: dual service as anaerobic electron acceptor and nitrogen source.Environmental microbiology · 2021Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C4-dicarboxylates, such as fumarate, l-malate and l-aspartate represent substrates for anaerobic growth of Escherichia coli by fumarate respiration. Here, we determined whether C4-dicarboxylate metabolism, as well as fumarate respiration, contribute to colonization of the mammalian intestinal tract. Metabolite profiling revealed that the murine small intestine contained high and low levels of l-aspartate and l-malate respectively, whereas fumarate was nearly absent. Under laboratory conditions, addition of C4-dicarboxylate at concentrations corresponding to the levels of the C4-dicarboxylates in the small intestine (2.6 mmol kg
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