ArticleMovement disorders : official journal of the Movement Disorder Society2021
Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder.
Article in Movement disorders : official journal of the Movement Disorder Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Recent advances (2022-2024) in eye-tracking for Parkinson's disease: a promising tool for diagnosing and monitoring symptoms.Frontiers in aging neuroscience · 2025Pooled it
- Exploring eye movement abnormalities as objective biomarkers for Parkinson's disease utilizing virtual reality-based eye tracking.BMC neurology · 2026Article
- Saccade, pupil, and blink abnormalities in prodromal and manifest alpha-synucleinopathies.Journal of Parkinson's disease · 2025Article
- Multimodal oculomotor assessment reveals prodromal markers of Parkinson's disease in non-manifesting LRRK2 G2019S mutation carriers.NPJ Parkinson's disease · 2024Article
- Blink rate during saccadic eye movements: insights from patients with chronic pain.Journal of medicine and life · 2024Article
- Age-related changes in pupil dynamics and task modulation across the healthy lifespan.Frontiers in neuroscience · 2024Article
- Machine Learning and Eye Movements Give Insights into Neurodegenerative Disease Mechanisms.Sensors (Basel, Switzerland) · 2023Review
- Chromatic pupillometry for evaluating melanopsin retinal ganglion cell function in Alzheimer's disease and other neurodegenerative disorders: a review.Frontiers in psychology · 2023Review
- Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases.Brain communications · 2023Article
- A novel tablet-based software for the acquisition and analysis of gaze and eye movement parameters: a preliminary validation study in Parkinson's disease.Frontiers in neurology · 2023Article
- Eye tracking identifies biomarkers in α-synucleinopathies versus progressive supranuclear palsy.Journal of neurology · 2022Article
- Chromatic Pupillometry in Isolated Rapid Eye Movement Sleep Behavior Disorder.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Stereopsis and Eye Movement Abnormalities in Parkinson's Disease and Their Clinical Implications.Frontiers in aging neuroscience · 2022Article
- Abnormalities of Resting-State Electroencephalographic Microstate in Rapid Eye Movement Sleep Behavior Disorder.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundParkinson's disease (PD) patients exhibit deficits in saccade performance, pupil function, and blink rate. Isolated REM (rapid eye movement) Sleep Behavior Disorder (RBD) is a harbinger to PD making them candidates to investigate for early oculomotor abnormalities as PD biomarkers.
objectivesWe tested whether saccade, pupillary, and blink responses in RBD were similar to PD.
methodsRBD (n = 22), PD (n = 22) patients, and healthy controls (CTRL) (n = 74) were studied with video-based eye-tracking.
resultsRBD patients did not have significantly different saccadic behavior compared to CTRL, but PD patients differed from CTRL and RBD. Both patient groups had significantly lower blink rates, dampened pupil constriction, and dilation responses compared to CTRL.
conclusionRBD and PD patients had altered pupil and blink behavior compared to CTRL. Because RBD saccade parameters were comparable to CTRL, pupil and blink brain areas may be impacted before saccadic control areas, making them potential prodromal PD biomarkers. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.