Evidence map›Paper›PMID 33754278›Full record

ArticleFamilial cancer2022

Adaptation and early implementation of the PREdiction model for gene mutations (PREMM

Kathleen F Mittendorf, Chinedu Ukaegbu, Marian J Gilmore, Nangel M Lindberg, Tia L Kauffman, Donna J Eubanks, Elizabeth Shuster, Jake Allen, Carmit McMullen, Heather Spencer Feigelson and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Familial cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
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  10. Development and Validation of the PREMMplus Model for Multigene Hereditary Cancer Risk Assessment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Kathleen F Mittendorf *Department of Translational and Applied Genomics, Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA. kathleen.f.mittendorf@kpchr.org.ORCID 0000-0003-1097-9171
Chinedu Ukaegbu *Dana Farber Cancer Institute, Boston, MA, USA.
Marian J GilmoreDepartment of Translational and Applied Genomics, Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Nangel M LindbergCenter for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Tia L KauffmanDepartment of Translational and Applied Genomics, Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Donna J EubanksCenter for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Elizabeth ShusterCenter for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Jake AllenCenter for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Carmit McMullenCenter for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Heather Spencer FeigelsonInstitute for Health Research, Kaiser Permanente, Denver, CO, USA.
Katherine P AndersonDenver Health and Hospital Authority, Denver, CO, USA.
Michael C LeoCenter for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Jessica Ezzell HunterDepartment of Translational and Applied Genomics, Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Sonia Okuyama SasakiDenver Health and Hospital Authority, Denver, CO, USA.
Jamilyn M ZeppDepartment of Translational and Applied Genomics, Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Sapna SyngalDana Farber Cancer Institute, Boston, MA, USA.
Benjamin S WilfondTreuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute and Hospital, Seattle, WA, USA.
Katrina A B GoddardDepartment of Translational and Applied Genomics, Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
Kaiser Permanente Center for Health Research · USDenver Health Medical Center · USBrigham and Women's Hospital · USHarvard University · USKaiser Permanente · USSeattle Children's Hospital · US

Funding

Exome sequencing in Diverse Populations in Colorado & OregonU01HG007292 · NHGRI · KAISER FOUNDATION RESEARCH INSTITUTE · PI LEO, MICHAEL C, WILFOND, BENJAMIN SIMON · 2017 to 2021
$15.7M
TRAINING GRANT IN GENETICST32GM007748 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Anne O'Donnell-Luria, Louise Wilkins-Haug · 1985 to 2026
$12.0M
Clinical Implementation of Carrier Testing using NGSUM1HG007292 · NHGRI · KAISER FOUNDATION RESEARCH INSTITUTE · PI GODDARD, KATRINA A., WILFOND, BENJAMIN SIMON · 2013 to 2016
$8.2M
Evolving Our Partnership: The CSER2 Centralized Support Coordinating CenterU24HG007307 · NHGRI · UNIVERSITY OF WASHINGTON · PI FULLERTON, STEPHANIE MALIA, JARVIK, GAIL PAIRITZ · 2017 to 2021
$5.8M
Validation and extension of the PREMM Model for mismatch repair gene mutationsR01CA132829 · NCI · DANA-FARBER CANCER INST · PI SYNGAL, SAPNA · 2008 to 2022
$5.6M
NCI NIH HHS R01 CA132829NHGRI NIH HHS U01 HG007292NHGRI NIH HHS U24 HG007307NHGRI NIH HHS UM1 HG007292
6 · The paper itself

Abstract

Lynch syndrome (LS) is the most common inherited cause of colorectal and endometrial cancers. Identifying individuals at risk for LS without personal cancer history requires detailed collection and assessment of family health history. However, barriers exist to family health history collection, especially in historically underserved populations. To improve LS risk assessment in historically underserved populations, we adapted the provider-facing PREdiction Model for gene Mutations (PREMM

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisEndometrial NeoplasmsFemaleHumansMicrosatellite InstabilityMutationRisk AssessmentFamily historyHereditary cancerLynch syndromeRisk assessmentUnderserved

Identifiers

PMID33754278
PMCPMC8458476
OpenAlexW3137540956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.