Evidence map›Paper›PMID 33754060›Full record

ArticleTheranostics2021

Thymosin β4 released from functionalized self-assembling peptide activates epicardium and enhances repair of infarcted myocardium.

Yong-Li Wang, Shu-Na Yu, Hao-Ran Shen, Hai-Jie Wang, Xue-Ping Wu, Qiang-Li Wang, Bin Zhou, Yu-Zhen Tan

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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  9. Lymphangiogenesis: A new strategy for heart disease treatment (Review).International journal of molecular medicine · 2024
    Review
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  11. c-kitStem cell reviews and reports · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yong-Li WangDepartment of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China.
Shu-Na YuDepartment of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China.
Hao-Ran ShenDepartment of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China.
Hai-Jie WangDepartment of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China.
Xue-Ping WuDepartment of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China.
Qiang-Li WangDepartment of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China.
Bin ZhouShanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200032, China.
Yu-Zhen TanDepartment of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China.
Shanghai Medical College of Fudan University · CNShanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epicardium plays an important role in cardiomyogenesis during development, while it becomes quiescent in adult heart during homeostasis. This study investigates the efficiency of thymosin β4 (Tβ4) release with RPRHQGVM conjugated to the C-terminus of RADA16-I (RADA-RPR), the functionalized self-assembling peptide (SAP), to activate the epicardium and repairing the infarcted myocardium.

Indexed as

AnimalsCell DifferentiationCell MovementCell ProliferationEndothelial CellsLymphangiogenesisMiceMice, TransgenicMyocardial InfarctionMyocardiumMyocytes, CardiacNeovascularization, PhysiologicPeptidesPericardiumThymosinThymosin beta(4)PeptidesThymosinThymosin beta(4)epicardiumepicardium-derived cellsmyocardial infarctionself-assembling peptidethymosin beta 4

Identifiers

PMID33754060
PMCPMC7977468
OpenAlexW3137507555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.