Evidence map›Paper›PMID 33754049›Full record

ArticleTheranostics2021

Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus.

Na-Na Yang, Jing-Wen Yang, Yang Ye, Jin Huang, Lu Wang, Yu Wang, Xin-Tong Su, Ying Lin, Fang-Ting Yu, Si-Ming Ma and 6 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 9 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 9 syntheses or guidelines pooled it, 182 citations in OpenAlex.

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  4. Influence of acupuncture and moxibustion on gastrointestinal function and adverse events in gastric cancer patients after surgery and chemotherapy: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Na-Na YangInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Jing-Wen YangInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Yang YeDepartment of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China.
Jin HuangInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Lu WangInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Yu WangInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Xin-Tong SuInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Ying LinInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Fang-Ting YuInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Si-Ming MaInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Ling-Yu QiInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Lu-Lu LinInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Li-Qiong WangInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Guang-Xia ShiInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Hong-Ping LiInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Cun-Zhi LiuInternational Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine.
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory cytokines produced by muscularis macrophages largely contribute to the pathological signs of postoperative ileus (POI). Electroacupuncture (EA) can suppress inflammation, mainly or partly via activation of vagal efferent. The goal of this study was to investigate the mechanisms by which EA stimulation at an hindlimb region ameliorates inflammation in POI.

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnimalsCytokinesElectroacupunctureIleusInflammationIntestinesJanus Kinase 2MacrophagesMiceMice, Inbred C57BLParasympathetic Nervous SystemPostoperative ComplicationsSignal TransductionSTAT3 Transcription FactorVagus Nervealpha7 Nicotinic Acetylcholine ReceptorCytokinesJak2 protein, mouseJanus Kinase 2Stat3 protein, mouseSTAT3 Transcription FactorGABAA receptorgastrointestinal motilityJAK2/STAT3 signaling pathwaymacrophagesα7nAChR

Identifiers

PMID33754049
PMCPMC7977469
OpenAlexW3139490156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.