ArticleTheranostics2021
miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (
Open access · goldAbstract read
In one paragraph
Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Exosome-like nanoparticles derived from fruits, vegetables, and herbs: innovative strategies of therapeutic and drug delivery.Theranostics · 2024Pooled it
- Identifying MicroRNA Biomarkers in Idiopathic Intracranial Hypertension: A Pilot Study.Neurology · 2026Trial
- Natural Product-Derived Vesicles in Nanotherapeutics.Journal of extracellular vesicles · 2026Review
- Grape-Derived Exosome-like Nanoparticles Ameliorate Prediabetes in Mice via Amino Acid Metabolic Reprogramming.International journal of molecular sciences · 2026Article
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- Targeting VAMPs in Aging-Related Diseases: From Mechanisms to Pharmacotherapy.Pharmaceutical research · 2026Review
- Plant-Derived Nanovesicles: A Comprehensive Review from Isolation to Clinical Translation-Unlocking Natural Nanocarriers for Biomedical Applications.Biomolecules · 2026Review
- MicroRNA 375 and diabetes: A key regulator of β cell function and a promising non-invasive biomarker.World journal of diabetes · 2025Review
- Dynamic Rendition of Adipose Genes Under Epigenetic Regulation: Revealing New Mechanisms of Obesity Occurrence.Current issues in molecular biology · 2025Review
- Exploring the link between environmental chemical exposures and epigenetic modifications in diabetes mellitus: A review.Biomolecules & biomedicine · 2025Review
- Ginger exosome-like nanoparticle-derived miRNA therapeutics: A strategic inhibitor of intestinal inflammation.Journal of advanced research · 2025Article
- Host-dependent alteration of the gut microbiota: the role of luminal microRNAs.Microbiome research reports · 2025Review
- Revolutionizing medicine: Harnessing plant-derived vesicles for therapy and drug transport.Heliyon · 2024Review
- Alterations in the Levels of Urinary Exosomal MicroRNA-183-5p and MicroRNA-125a-5p in Individuals with Type 2 Diabetes Mellitus.Biomedicines · 2024Article
- Review
- Momordica charantia L.-derived exosome-like nanovesicles stabilize p62 expression to ameliorate doxorubicin cardiotoxicity.Journal of nanobiotechnology · 2024Article
- Ginger-derived nanovesicles attenuate osteoarthritis progression by inhibiting oxidative stress via the Nrf2 pathway.Nanomedicine (London, England) · 2024Article
- MicroRNAs as Epigenetic Regulators of Obesity.Advances in experimental medicine and biology · 2024Review
- Emerging Trends in the Application of Extracellular Vesicles as Novel Oral Delivery Vehicles for Therapeutics in Inflammatory Diseases.International journal of nanomedicine · 2024Review
- Circulating miRNAs as Biomarkers of Subclinical Atherosclerosis Associated with Severe Obesity before and after Bariatric Surgery.Obesity facts · 2024Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Anil KumarJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
Yi RenDepartment of Breast and Thyroid Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, China.
Kumaran SundaramJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
Jingyao MuJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
Mukesh K SriwastvaJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
Gerald W DrydenJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
Chao LeiJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
Lifeng ZhangJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
Jun YanJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
Xiang ZhangDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
Juw Won ParkDepartment of Computer Engineering and Computer Science, University of Louisville, KY 40202, USA.
Michael L MerchantKidney Disease Program and Clinical Proteomics Center, University of Louisville, Louisville, KY, USA.
Yun TengJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
Huang-Ge ZhangJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
University of Louisville · USLouisville VA Medical Center · USNanjing Medical University · CN
Funding
WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1MUnderstanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative IntravaginalP20GM125504 · NIGMS · UNIVERSITY OF LOUISVILLE · PI Shirin Ghods · 2018 to 2026
$24.4MRole of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1MThe Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9MUniversity of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0MPlant exosomes non-coding RNA-mediated anti-inflammatory mechanismsR01AT008617 · NCCIH · UNIVERSITY OF LOUISVILLE · PI HUANG-GE ZHANG · 2016 to 2026
$5.7MNCCIH NIH HHS R01 AT008617NIAAA NIH HHS P50 AA024337NIEHS NIH HHS P30 ES030283NIGMS NIH HHS P20 GM103436NIGMS NIH HHS P20 GM113226NIGMS NIH HHS P20 GM125504
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAnimalsBacteriaBasic Helix-Loop-Helix ProteinsCells, CulturedDiet, High-FatHepatocytesHumansInsulinInsulin ResistanceLipidsLiverMaleMiceMice, Inbred C57BLMice, KnockoutAhr protein, mouseBasic Helix-Loop-Helix ProteinsInsulinLipidsMicroRNAsMirn375 microRNA, mouseReceptors, Aryl HydrocarbonR-SNARE ProteinsTryptophanaseAhRE. coli tryptophanase (tnaA)ExosomesGinger derived nanoparticlesgut/liver axisindoleinsulin resistance.miR-375VAMP7
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.