Evidence map›Paper›PMID 33754024›Full record

ArticleTheranostics2021

GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity.

Jian Lu, Pei Pei Chen, Jia Xiu Zhang, Xue Qi Li, Gui Hua Wang, Ben Yin Yuan, Si Jia Huang, Xiao Qi Liu, Ting Ting Jiang, Meng Ying Wang and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05838118 (Washed Microbiota Transplantation), which is not on this map. Cited by 67 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 5 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05838118 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Washed Microbiota Transplantation (WMT) for Chronic Kidney Disease (CKD): a Open Label, Multicenter Trial

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2023 to 2024Enrolled100ConditionsCKDArmsFecal Microbiota Transplantation, Standard of Care for Chronic Kidney Disease
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 5 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. The roles of free-fatty acid receptors in the pathophysiology of renal disorders.The Journal of pharmacology and experimental therapeutics · 2026
    Review
  12. Article
  13. Review
  14. Post‑translational modifications in diabetic kidney disease (Review).International journal of molecular medicine · 2026
    Review
  15. Article
  16. Podocyte Metabolic Reprogramming and Targeted Therapy.Journal of the American Society of Nephrology : JASN · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Jian LuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Pei Pei ChenInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Jia Xiu ZhangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Xue Qi LiInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Gui Hua WangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Ben Yin YuanInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Si Jia HuangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Xiao Qi LiuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Ting Ting JiangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Meng Ying WangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Wen Tao LiuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Xiong Zhong RuanJohn Moorhead Research Laboratory, Department of Renal Medicine, University College London (UCL) Medical School, Royal Free Campus, London, NW3 2PF, UK.
Bi Cheng LiuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Kun Ling MaInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Zhongda Hospital Southeast University · CNUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAMP-Activated Protein KinasesAnimalsDiabetes Mellitus, ExperimentalDiabetic NephropathiesDysbiosisFecal Microbiota TransplantationFemaleGastrointestinal MicrobiomeHumansInsulin ResistanceKidneyMaleMiceMice, KnockoutAMP-Activated Protein KinasesFFAR2 protein, humanFfar2 protein, mouseFfar2 protein, ratReceptors, Cell SurfaceReceptors, G-Protein-CoupledAMPKα activitydiabetic nephropathyGPR43gut microbiota dysbiosispodocyte insulin resistance

Identifiers

PMID33754024
PMCPMC7978296
OpenAlexW3136566870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.