Evidence map›Paper›PMID 33754023›Full record

ArticleTheranostics2021

Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice

Yin Cai, Hao Liu, Erfei Song, Lin Wang, Jindong Xu, Yi He, Dengwen Zhang, Liyan Zhang, Kenneth King-Yip Cheng, Leigang Jin and 8 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
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  5. Article
  6. Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Type 2 Diabetes From the Perspective of Telomere Biology.Endocrinology, diabetes & metabolism · 2026
    Review
  11. Review
  12. Review
  13. Review
  14. Transcriptional regulation in cardiovascular aging.Frontiers in cardiovascular medicine · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Yin CaiState Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Hao LiuDepartment of Anaesthesiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou, Guangdong, China.
Erfei SongThe First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.
Lin WangState Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Jindong XuDepartment of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong, China.
Yi HeDepartment of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong, China.
Dengwen ZhangDepartment of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong, China.
Liyan ZhangCardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Kenneth King-Yip ChengDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Leigang JinState Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Min WuDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong, China.
Shiming LiuDepartment of Cardiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou, Guangdong, China.
Dake QiDivision of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, Newfoundland, Canada.
Liangqing ZhangDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Gary D LopaschukCardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Sheng WangDepartment of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong, China.
Aimin XuState Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Zhengyuan XiaState Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Guangdong Academy of Medical Sciences · CNUniversity of Hong Kong · HKGuangdong Medical College · CNHong Kong Polytechnic University · HKUniversity of Alberta · CAFirst Affiliated Hospital of Jinan University · CNGuangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingAnimalsBenzothiazolesCardiomegalyCellular SenescenceDNA DamageEchocardiographyFatty AcidsHeart DiseasesHistonesMiceMice, KnockoutMitochondria, HeartMyocytes, CardiacOpen Field TestPeroxisome ProliferatorsBenzothiazolesFatty Acidsgamma-H2AX protein, mouseHistonesPeroxisome Proliferatorspifithrinpirinixic acidPPAR alphaPpara protein, mousePyrimidinesShelterin ComplexTelomere-Binding ProteinsTERF2IP protein, mouseTolueneTrp53 protein, mouseTumor Suppressor Protein p53cardiac agingfatty acid metabolismp53PPARαRap1

Identifiers

PMID33754023
PMCPMC7978321
OpenAlexW3136265970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.