Evidence map›Paper›PMID 33754012›Full record

ArticleJournal of Cancer2021

Exosomal miR-10b-5p mediates cell communication of gastric cancer cells and fibroblasts and facilitates cell proliferation.

Ting Yan, Xiaping Wang, Guohua Wei, Hai Li, Leiyu Hao, Yan Liu, Xinqian Yu, Wei Zhu, Ping Liu, Yichao Zhu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  7. Review
  8. Exosomal microRNAs: impact on cancer detection, treatment, and monitoring.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ting YanSafety Assessment and Research Center for Drug, Pesticide and Veterinary Drug of Jiangsu Province, Nanjing Medical University, Nanjing 211166, China.
Xiaping WangDepartment of Pathology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
Guohua WeiDepartment of Anesthesiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Hai LiDepartment of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Leiyu HaoDepartment of Physiology, Nanjing Medical University, Nanjing 211166, China.
Yan LiuDepartment of Physiology, Nanjing Medical University, Nanjing 211166, China.
Xinqian YuDepartment of Physiology, Nanjing Medical University, Nanjing 211166, China.
Wei ZhuDepartment of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Ping LiuDepartment of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Yichao ZhuDepartment of Physiology, Nanjing Medical University, Nanjing 211166, China.
Xin ZhouDepartment of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Nanjing Medical University · CNJiangsu Province Hospital · CNSecond Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor microenvironment interacts with gastric cancer (GC) cells and affects tumor development. The communication between GC cells and fibroblasts has not been clearly studied and understood. MiR-10b-5p was found highly expressed in tissue and serum samples of patients with advanced stages (stage III+IV) than that in early stage patients (stage I+II). The expression determination of serum exosomal microRNA was also shown with high expression of miR-10b-5p in GC patients with advanced stages. Dual-luciferase activity assays indicated that miR-10b-5p targeted

Indexed as

cell proliferationexosomefibroblastgastric cancermiR-10b-5p

Identifiers

PMID33754012
PMCPMC7974515
OpenAlexW3136261983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.