Evidence map›Paper›PMID 33753963›Full record

ArticleSensors and actuators. B, Chemical2021

Magnetic graphene quantum dots facilitate closed-tube one-step detection of SARS-CoV-2 with ultra-low field NMR relaxometry.

Yongqiang Li, Peixiang Ma, Quan Tao, Hans-Joachim Krause, Siwei Yang, Guqiao Ding, Hui Dong, Xiaoming Xie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors and actuators. B, Chemical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 45 citations in OpenAlex.

  1. Graphene-Oxide Peptide-Containing Materials for Biomedical Applications.International journal of molecular sciences · 2024
    Review
  2. Review
  3. Article
  4. Review
  5. COVID-19 diagnostics: Molecular biology to nanomaterials.Clinica chimica acta; international journal of clinical chemistry · 2023
    Review
  6. Article
  7. Review
  8. Quantum dots against SARS-CoV-2: diagnostic and therapeutic potentials.Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986) · 2022
    Review
  9. Review
  10. Nanoparticles for Coronavirus Control.Nanomaterials (Basel, Switzerland) · 2022
    Review
  11. Review
  12. Electrochemical sensors for the detection of SARS-CoV-2 virus.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yongqiang LiState Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.
Peixiang MaShanghai Institute for Advanced Immunological Studies, ShanghaiTech University, Shanghai, 201210, PR China.
Quan TaoState Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.
Hans-Joachim KrauseInstitute of Biological Information Processing (IBI-3), Forschungszentrum Jülich (FZJ), D-52425, Jülich, Germany.
Siwei YangState Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.
Guqiao DingState Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.
Hui DongState Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.
Xiaoming XieState Key Laboratory of Functional Materials of Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences, Shanghai, 200050, PR China.
Chinese Academy of Sciences · CNShanghai Institute of Microsystem and Information Technology · CNForschungszentrum Jülich · DEShanghaiTech University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid and sensitive diagnosis of the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the crucial issues at the outbreak of the ongoing global pandemic that has no valid cure. Here, we propose a SARS-CoV-2 antibody conjugated magnetic graphene quantum dots (GQDs)-based magnetic relaxation switch (MRSw) that specifically recognizes the SARS-CoV-2. The probe of MRSw can be directly mixed with the test sample in a fully sealed vial without sample pretreatment, which largely reduces the testers' risk of infection during the operation. The closed-tube one-step strategy to detect SARS-CoV-2 is developed with home-made ultra-low field nuclear magnetic resonance (ULF NMR) relaxometry working at 118 μT. The magnetic GQDs-based probe shows ultra-high sensitivity in the detection of SARS-CoV-2 due to its high magnetic relaxivity, and the limit of detection is optimized to 248 Particles mL

Indexed as

Ab, specific antibody against SARS-CoV-2 antigen S proteinAFM, atomic force microscopyBSA, bull serum albuminCOVID-19, coronavirus disease 2019ELISA, enzyme-linked immune-sorbent assayFe3O4, ferrosoferric oxideGPG, Gd3+ loaded PEG modified GQDsGQDs, graphene quantum dotsGraphene quantum dotsHR-TEM, high resolution TEMLOD, limit of detectionMagnetic relaxation switchMNPs, magnetic nanoparticlesMRSw, magnetic relaxation switchNMR, nuclear magnetic resonanceOSR, outer sphere relaxation theoryPBS, phosphate buffer salinePEG6, hexaethylene glycolPEG, polyethylene glycolRT-PCR, reverse transcription-polymerase chain reactionSARS-CoV-2SARS-CoV-2, severe acute respiratory syndrome coronavirus 2SD, standard deviationSpikeS protein, spike proteinSQUID, superconducting quantum interface deviceT1, longitudinal relaxation timeTEM, transmission electron microscopyULF NMR, ultra-low field NMRUltra-low field nuclear magnetic resonanceXPS, X-ray photoelectron spectroscopy

Identifiers

PMID33753963
PMCPMC7959688
OpenAlexW3136919398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.