ArticleNature neuroscience2021
Experience-dependent contextual codes in the hippocampus.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 97 citations in OpenAlex.
- Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex.Nature neuroscience · 2026Article
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- Lateral entorhinal cortex supports behaviorally-induced hippocampal ensemble stability for reliable memory recall.bioRxiv : the preprint server for biology · 2026Article
- Place field dynamics in retrosplenial cortex compared to hippocampus.Progress in neurobiology · 2026Article
- Unconstrained Plasticity Disrupts Memory Consolidation in a Mouse Model of Rett Syndrome.bioRxiv : the preprint server for biology · 2026Article
- The relevance of context in memory tasks influences the magnitude of hippocampal remapping.Cell reports · 2025Article
- Adaptation of hippocampal spatial and contextual representations to task structure.Science advances · 2025Article
- Learning neural dynamics through instructive signals.bioRxiv : the preprint server for biology · 2025Article
- Three types of remapping with linear decoders: A population-geometric perspective.PLoS computational biology · 2025Article
- REM sleep prefrontal ripple chains mediate distinct cortical-hippocampal reactivation patterns compared to NREM ripples.bioRxiv : the preprint server for biology · 2025Article
- Three types of remapping with linear decoders: a population-geometric perspective.bioRxiv : the preprint server for biology · 2025Article
- A flexible hippocampal population code for experience relative to reward.Nature neuroscience · 2025Article
- Formation of an expanding memory representation in the hippocampus.Nature neuroscience · 2025Article
- Mechanisms of experience-dependent place-cell referencing in hippocampal area CA1.Nature neuroscience · 2025Article
- Learning reshapes the hippocampal representation hierarchy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Navigating uncertainty: reward location variability induces reorganization of hippocampal spatial representations.bioRxiv : the preprint server for biology · 2025Article
- Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging.Molecular brain · 2024Article
- Space is a latent sequence: A theory of the hippocampus.Science advances · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The hippocampus contains neural representations capable of supporting declarative memory. Hippocampal place cells are one such representation, firing in one or few locations in a given environment. Between environments, place cell firing fields remap (turning on/off or moving to a new location) to provide a population-wide code for distinct contexts. However, the manner by which contextual features combine to drive hippocampal remapping remains a matter of debate. Using large-scale in vivo two-photon intracellular calcium recordings in mice during virtual navigation, we show that remapping in the hippocampal region CA1 is driven by prior experience regarding the frequency of certain contexts and that remapping approximates an optimal estimate of the identity of the current context. A simple associative-learning mechanism reproduces these results. Together, our findings demonstrate that place cell remapping allows an animal to simultaneously identify its physical location and optimally estimate the identity of the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.