Evidence map›Paper›PMID 33753942›Full record

ArticleNature immunology2021

Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias.

Mahesh Raundhal, Shrestha Ghosh, Samuel A Myers, Michael S Cuoco, Meromit Singer, Steven A Carr, Sushrut S Waikar, Joseph V Bonventre, Jerome Ritz, Richard M Stone and 3 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Navigating Anemia Therapy in CKD With Hypoxia-Inducible Factor Activators: A Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026
    Review
  3. Review
  4. Causality of Aging Hallmarks.Aging and disease · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Immunoregulation role of the erythroid cells.Frontiers in immunology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. IL-22 blockade alleviates anaemia.Nature reviews. Drug discovery · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Mahesh RaundhalDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. Mahesh_Raundhal@dfci.harvard.edu.ORCID http://orcid.org/0000-0001-8175-2957
Shrestha GhoshDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Samuel A MyersBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Michael S CuocoKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Meromit SingerDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sushrut S WaikarRenal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Joseph V BonventreRenal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7144-386X
Jerome RitzDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Richard M StoneDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
David P SteensmaDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Aviv RegevKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3293-3158
Laurie H GlimcherDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. Laurie_Glimcher@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-4971-0404
Broad Institute · USBrigham and Women's Hospital · USHarvard University · USBoston University · US

Funding

TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5M
Targeting SYK Kinase in AMLP50CA206963 · NCI · DANA-FARBER CANCER INST · PI STEGMAIER, KIMBERLY · 2017 to 2021
$10.6M
MICROSCALED PROTEOGENOMICS FOR CANCER CLINICAL TRIALSU01CA214125 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ANURAG, MEENAKSHI, CARR, STEVEN A · 2017 to 2021
$7.0M
Center of Excellence for High Throughput Proteogenomic CharacterizationU24CA210986 · NCI · BROAD INSTITUTE, INC. · PI CARR, STEVEN A, GILLETTE, MICHAEL A · 2016 to 2020
$6.4M
Mechanisms of Ischemic Kidney Injury and RepairR37DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1993 to 2021
$5.2M
Multi-faceted Roles of an Atypical Kinase RIOK2 in Erythropoiesis and Myelodyplastic SyndromesR03HL156574 · NHLBI · DANA-FARBER CANCER INST · PI GLIMCHER, LAURIE HOLLIS · 2020 to 2020
$177k
Howard Hughes Medical InstituteNCI NIH HHS P01 CA066996NCI NIH HHS P50 CA206963NCI NIH HHS U01 CA214125NCI NIH HHS U24 CA210986NHLBI NIH HHS R03 HL156574NIDDK NIH HHS R37 DK039773
6 · The paper itself

Abstract

Patients with myelodysplastic syndromes (MDSs) display severe anemia but the mechanisms underlying this phenotype are incompletely understood. Right open-reading-frame kinase 2 (RIOK2) encodes a protein kinase located at 5q15, a region frequently lost in patients with MDS del(5q). Here we show that hematopoietic cell-specific haploinsufficient deletion of Riok2 (Riok2

Indexed as

AnemiaAnimalsAntibodies, NeutralizingCells, CulturedCellular MicroenvironmentDisease Models, AnimalErythroid CellsErythropoiesisHumansInterleukin-22InterleukinsMiceMice, Inbred C57BLMice, KnockoutMyelodysplastic SyndromesProtein Serine-Threonine KinasesAntibodies, NeutralizingInterleukin-22interleukin-22 receptorInterleukinsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-vavReceptors, InterleukinRIOK2 protein, humanTP53 protein, humanTrp53 protein, mouseTumor Suppressor Protein p53VAV1 protein, humanVav1 protein, mouse

Identifiers

PMID33753942
PMCPMC8026551
OpenAlexW3135945997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.