ArticleInternational journal of obesity (2005)2021
Polygenic risk for obesity and its interaction with lifestyle and sociodemographic factors in European children and adolescents.
Article in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Polygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Interactions between Polygenic Risk of Obesity and Dietary Factors on Anthropometric Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.The Journal of nutrition · 2024Pooled it
- Effects of a physical activity intervention on schoolchildren fitness.Physiological reports · 2022Trial
- Genetic determinants of obesity: mechanisms, clinical implications, and targeted therapies.Endocrine · 2026Review
- Lifestyle and family factors associated with childhood overweight: evidence from a case-control study in Indonesian schoolchildren.Korean journal of family medicine · 2026Article
- Interaction between polygenic scores and dietary intake in relation to BMI in Canadian children.Journal of nutritional science · 2026Article
- Modifiable lifestyle factors and genetic risk of obesity in Indians.Scientific reports · 2025Article
- Association between clock genes polygenic risk score for depression and obesity in a population with high burden of obesity.Nutrition & metabolism · 2025Article
- Mediterranean diet and obesity polygenic risk interaction on adiposity in European children: The IDEFICS/I.Family Study.Pediatric obesity · 2025Article
- Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies.International journal of molecular sciences · 2025Review
- Risk factors and prediction for pediatric obesity: current status and future perspectives.Endocrine journal · 2025Review
- Editorial: Precision nutrition and nutrients: making the promise a reality.Frontiers in nutrition · 2025Article
- Validation of a genome-wide polygenic score for body mass index in South Asians.Frontiers in genetics · 2025Article
- Article
- Beyond sport to combat childhood obesity: educating, engaging, and preventing through an integrated school-based campaign grounded in the values of Olympism.Frontiers in endocrinology · 2025Article
- Socioeconomic disadvantage and polygenic risk of overweight in early and mid-life: a longitudinal population cohort study spanning 12 years.The Lancet regional health. Western Pacific · 2024Article
- Variability of polygenic prediction for body mass index in Africa.Genome medicine · 2024Article
- Exploring Maternal Diet-Epigenetic-Gut Microbiome Crosstalk as an Intervention Strategy to Counter Early Obesity Programming.Current issues in molecular biology · 2024Review
- Socio-economic differences in body mass index: the contribution of genetic factors.International journal of obesity (2005) · 2024Article
- Future implications of polygenic risk scores for life insurance underwriting.NPJ genomic medicine · 2024Review
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Authors and funding
13 authors.
Funding
Abstract
backgroundChildhood obesity is a complex multifaceted condition, which is influenced by genetics, environmental factors, and their interaction. However, these interactions have mainly been studied in twin studies and evidence from population-based cohorts is limited. Here, we analyze the interaction of an obesity-related genome-wide polygenic risk score (PRS) with sociodemographic and lifestyle factors for BMI and waist circumference (WC) in European children and adolescents.
methodsThe analyses are based on 8609 repeated observations from 3098 participants aged 2-16 years from the IDEFICS/I.Family cohort. A genome-wide polygenic risk score (PRS) was calculated using summary statistics from independent genome-wide association studies of BMI. Associations were estimated using generalized linear mixed models adjusted for sex, age, region of residence, parental education, dietary intake, relatedness, and population stratification.
resultsThe PRS was associated with BMI (beta estimate [95% confidence interval (95%-CI)] = 0.33 [0.30, 0.37], r
conclusionsOur results highlight that a healthy childhood environment might partly offset a genetic predisposition to obesity during childhood and adolescence.
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