Evidence map›Paper›PMID 33753848›Full record

ArticleScientific reports2021

A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes.

Timothy Warwick, Marcel H Schulz, Stefan Günther, Ralf Gilsbach, Antonio Neme, Carsten Carlberg, Ralf P Brandes, Sabine Seuter

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 49 citations in OpenAlex.

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  16. Review
  17. Vitamin D Receptor Regulates the Expression of the Grainyhead-Like 1 Gene.International journal of molecular sciences · 2024
    Article
  18. Role of Calcitriol and Vitamin D Receptor (International journal of molecular sciences · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Timothy WarwickInstitute for Cardiovascular Physiology, Medical Faculty, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Marcel H SchulzInstitute for Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany.
Stefan GüntherMax-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
Ralf GilsbachInstitute for Cardiovascular Physiology, Medical Faculty, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Antonio NemeSchool of Medicine, Institute of Biomedicine, University of Eastern Finland, 70211, Kuopio, Finland.
Carsten CarlbergSchool of Medicine, Institute of Biomedicine, University of Eastern Finland, 70211, Kuopio, Finland.
Ralf P BrandesInstitute for Cardiovascular Physiology, Medical Faculty, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Sabine SeuterInstitute for Cardiovascular Physiology, Medical Faculty, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. seuter@vrc.uni-frankfurt.de.
Goethe University Frankfurt · DEUniversity of Eastern Finland · FIGerman Centre for Cardiovascular Research · DEMax Planck Institute for Heart and Lung Research · DEUniversidad Nacional Autónoma de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcription factor vitamin D receptor (VDR) is the high affinity nuclear target of the biologically active form of vitamin D

Indexed as

CCAAT-Enhancer-Binding ProteinsCholecalciferolCRISPR-Cas SystemsGene Expression RegulationGene Knockout TechniquesGene Regulatory NetworksGenome, HumanHumansMonocytesProto-Oncogene Protein c-ets-1Receptors, CalcitriolRNA-SeqTranscriptomeVitamin DCCAAT-Enhancer-Binding ProteinsCEBPA protein, humanCholecalciferolETS1 protein, humanProto-Oncogene Protein c-ets-1Receptors, CalcitriolVDR protein, humanVitamin D

Identifiers

PMID33753848
PMCPMC7985518
OpenAlexW3136988459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.