ArticleScientific reports2021
Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Serum biomarkers in prednisolone-treated hand osteoarthritis patients.Rheumatology (Oxford, England) · 2023Trial
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- Movement smoothness and plasma proteomics are associated with functional impairment in knee osteoarthritis.Osteoarthritis and cartilage open · 2026Article
- Effect of Physical Therapy on Inflammatory Biomarkers in Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis.Exploration (Beijing, China) · 2026Review
- Inflammatory, angiogenic and neurogenic serum biomarkers in patients with patellofemoral pain compared to healthy controls.Osteoarthritis and cartilage open · 2026Article
- Clinico-Laboratory Correlates of Inflammatory Markers in Elderly Knee Osteoarthritis.Journal of orthopaedic case reports · 2026Article
- Feasibility of a Preoperative Exercise and Nutritional Intervention in Sarcopenic Obese Individuals Undergoing Hip or Knee Arthroplasty: A Pilot Randomized Controlled Trial.Archives of rehabilitation research and clinical translation · 2025Article
- Towards stratification in osteoarthritis: a review of the scientific terminology used in published basic research.BMC rheumatology · 2025Review
- Clinical and radiological evaluation of osteoarthritis in knee pain patients and its association with inflammatory markers at MGM Medical College Hospital, Jamshedpur.Journal of family medicine and primary care · 2025Article
- Proteomic analysis reveals biomarkers associated with performance-based joint function and patient-reported outcomes in knee osteoarthritis.Osteoarthritis and cartilage open · 2025Article
- Risk factors associated with knee osteoarthritis severity and their correlation with Kellgren-Lawrence grade.Frontiers in medicine · 2025Article
- Inflammatory burden index: associations between osteoarthritis and all-cause mortality among individuals with osteoarthritis.BMC public health · 2024Article
- An osteoarthritis pathophysiological continuum revealed by molecular biomarkers.Science advances · 2024Article
- Association of biochemical markers with bone marrow lesion changes on imaging-data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.Arthritis research & therapy · 2024Article
- Pathological tissue formation and degradation biomarkers correlate with patient reported pain outcomes: an explorative study.Osteoarthritis and cartilage open · 2023Article
- Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies.International journal of molecular sciences · 2022Review
- Blood and urine biomarkers in osteoarthritis - an update on cartilage associated type II collagen and aggrecan markers.Current opinion in rheumatology · 2022Review
- Increased serum AXL is associated with radiographic knee osteoarthritis severity.International journal of rheumatic diseases · 2022Article
- A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis.Arthritis research & therapy · 2021Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heterogeneous nature of osteoarthritis (OA) and the need to subtype patients is widely accepted in the field. The biomarker CRPM, a metabolite of C-reactive protein (CRP), is released to the circulation during inflammation. Blood CRPM levels have shown to be associated with disease activity and response to treatment in rheumatoid arthritis (RA). We investigated the level of blood CRPM in OA compared to RA using data from two phase III knee OA and two RA studies (N = 1591). Moreover, the association between CRPM levels and radiographic progression was investigated. The mean CRPM levels were significantly lower in OA (8.5 [95% CI 8.3-8.8] ng/mL, n = 781) compared to the RA patients (12.8 [9.5-16.0] ng/mL, n = 60); however, a significant subset of OA patients (31%) had CRPM levels (≥ 9 ng/mL) comparable to RA. Furthermore, OA patients (n = 152) with CRPM levels ≥ 9 ng/mL were more likely to develop contra-lateral knee OA assessed by X-ray over a two-year follow-up period with an odds ratio of 2.2 [1.0-4.7]. These data suggest that CRPM is a blood-based biochemical marker for early identification OA patients with an inflammatory phenotype.
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