ArticleScientific reports2021
Transcranial focused ultrasound phase correction using the hybrid angular spectrum method.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- From Skull Density Ratio-based eligibility to efficiency-informed planning: Predictive modeling of thermal response in MR-guided focused ultrasound.Medical physics · 2026Article
- Focused ultrasound blood-brain barrier opening reveals a paradoxical remote metabolic response in the primate brain.Science advances · 2026Article
- Performance of a through-transmit aberration correction method for transcranial focused ultrasound: Simulation and experimental evaluation.The Journal of the Acoustical Society of America · 2026Article
- In vivo acoustoelectric neural recording in mice enabled by ultrasound-induced frequency mixing.Communications engineering · 2026Article
- A deep-learning model for one-shot transcranial ultrasound simulation and phase aberration correction.Medical physics · 2026Article
- De-aberration for noninvasive transcranial photoacoustic computed tomography through an adult human skull.Communications physics · 2026Article
- From Ablation to Neuromodulation Platform: The Evolving Role of Magnetic Resonance-Guided Focused Ultrasound in Functional Neurosurgery.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Focal volume, steering, and aberration correction in transcranial focused ultrasound: reconsidering the tradeoffs between single-element transducers, phased arrays, and acoustic holograms.Frontiers in neuroscience · 2026Article
- Article
- Aberration correction expands the treatment envelope for histotripsy in the liver.Physics in medicine and biology · 2025Article
- The speed of sound in skull-mimicking digital phantoms depends on the microstructure.Physics in medicine and biology · 2025Article
- Quantification of the relative contribution of phase aberration and reverberation in transcranial ultrasound imaging: an experimentally calibrated fullwave study in 2D and 3D.Physics in medicine and biology · 2025Article
- Clutter-Generating Phantom Material. Part II: Utilization in the Comparison of Conventional and Regularized Ultrasound Attenuation Estimation.Ultrasound in medicine & biology · 2025Article
- New technique for direct targeting of the ventral intermediate nucleus using magnetic resonance-guided focused ultrasound.Frontiers in radiology · 2025Article
- Treatment envelope of transcranial histotripsy: challenges and strategies to maximize the treatment location profile.Physics in medicine and biology · 2024Article
- Robust deep learning estimation of cortical bone porosity from MR T1-weighted images for individualized transcranial focused ultrasound planning.medRxiv : the preprint server for health sciences · 2024Article
- A novel transcranial MR Guided focused ultrasound method based on the ultrashort echo time skull acoustic model and phase retrieval techniques.Scientific reports · 2024Article
- Aberration correction in abdominal histotripsy.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- Transcranial ultrasound neuromodulation of the thalamic visual pathway in a large animal model and the dose-response relationship with MR-ARFI.Scientific reports · 2022Article
- Two-step aberration correction: application to transcranial histotripsy.Physics in medicine and biology · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
The InSightec Exablate system is the standard of care used for transcranial focused ultrasound ablation treatments in the United States. The system calculates phase corrections that account for aberrations caused by the human skull. This work investigates whether skull aberration correction can be improved by comparing the standard of care InSightec ray tracing method with the hybrid angular spectrum (HAS) method and the gold standard hydrophone method. Three degassed ex vivo human skulls were sonicated with a 670 kHz hemispherical phased array transducer (InSightec Exablate 4000). Phase corrections were calculated using four different methods (straight ray tracing, InSightec ray tracing, HAS, and hydrophone) and were used to drive the transducer. 3D raster scans of the beam profiles were acquired using a hydrophone mounted on a 3-axis positioner system. Focal spots were evaluated using six metrics: pressure at the target, peak pressure, intensity at the target, peak intensity, positioning error, and focal spot volume. For three skulls, the InSightec ray tracing method achieved 52 ± 21% normalized target intensity (normalized to hydrophone), 76 ± 17% normalized peak intensity, and 0.72 ± 0.47 mm positioning error. The HAS method achieved 74 ± 9% normalized target intensity, 81 ± 9% normalized peak intensity, and 0.35 ± 0.09 mm positioning error. The InSightec-to-HAS improvement in focal spot targeting provides promise in improving treatment outcomes. These improvements to skull aberration correction are also highly relevant for the applications of focused ultrasound neuromodulation and blood brain barrier opening, which are currently being translated for human use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.