Evidence map›Paper›PMID 33753769›Full record

ArticleScientific reports2021

Learned spectral decoloring enables photoacoustic oximetry.

Janek Gröhl, Thomas Kirchner, Tim J Adler, Lina Hacker, Niklas Holzwarth, Adrián Hernández-Aguilera, Mildred A Herrera, Edgar Santos, Sarah E Bohndiek, Lena Maier-Hein

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Depth-dependent fluence compensation withoutJournal of biomedical optics · 2025
    Article
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  17. Guided Multispectral Optoacoustic Tomography for 3D Imaging of the Murine Colon.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Janek GröhlComputer Assisted Medical Interventions, German Cancer Research Center, Heidelberg, Germany. j.groehl@dkfz.de.
Thomas KirchnerInstitute of Applied Physics, Biomedical Photonics, Bern University, Bern, Switzerland.
Tim J AdlerComputer Assisted Medical Interventions, German Cancer Research Center, Heidelberg, Germany.
Lina HackerDepartment of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.
Niklas HolzwarthComputer Assisted Medical Interventions, German Cancer Research Center, Heidelberg, Germany.
Adrián Hernández-AguileraDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Mildred A HerreraDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Edgar SantosDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Sarah E BohndiekDepartment of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.
Lena Maier-HeinComputer Assisted Medical Interventions, German Cancer Research Center, Heidelberg, Germany. l.maier-hein@dkfz.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of photoacoustic imaging to measure functional tissue properties, such as blood oxygenation sO[Formula: see text], enables a wide variety of possible applications. sO[Formula: see text] can be computed from the ratio of oxyhemoglobin HbO[Formula: see text] and deoxyhemoglobin Hb, which can be distuinguished by multispectral photoacoustic imaging due to their distinct wavelength-dependent absorption. However, current methods for estimating sO[Formula: see text] yield inaccurate results in realistic settings, due to the unknown and wavelength-dependent influence of the light fluence on the signal. In this work, we propose learned spectral decoloring to enable blood oxygenation measurements to be inferred from multispectral photoacoustic imaging. The method computes sO[Formula: see text] pixel-wise, directly from initial pressure spectra [Formula: see text], which represent initial pressure values at a fixed spatial location [Formula: see text] over all recorded wavelengths [Formula: see text]. The method is compared to linear unmixing approaches, as well as pO[Formula: see text] and blood gas analysis reference measurements. Experimental results suggest that the proposed method is able to obtain sO[Formula: see text] estimates from multispectral photoacoustic measurements in silico, in vitro, and in vivo.

Identifiers

PMID33753769
PMCPMC7985523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.