ArticleNature communications2021
Asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Synergistic Catalysis: Integrating Acids, Metals, and Light in Nature-Inspired Asymmetric Multicomponent Synthesis.Topics in current chemistry (Cham) · 2026Review
- Tetrachloromethane as an editable all-carbon quaternary source.Nature communications · 2026Article
- Enantioselective Alkoxycarbonyl-Lactonization of Alkenes via the Merger of Photoredox and Copper Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Asymmetric cyanoesterification of vinylarenes by electrochemical copper catalysis.Nature communications · 2025Article
- General Alkene 1,2-Journal of the American Chemical Society · 2024Article
- Overcoming Copper Reduction Limitation in Asymmetric Substitution: Aryl-Radical-Enabled Enantioconvergent Cyanation of Alkyl Iodides.Journal of the American Chemical Society · 2024Article
- Manganese-catalyzed base-free addition of saturated nitriles to unsaturated nitriles by template catalysis.Chemical science · 2024Article
- Nickel-catalysed enantioselective alkene dicarbofunctionalization enabled by photochemical aliphatic C-H bond activation.Nature catalysis · 2024Article
- Enantioselective catalytic radical decarbonylative azidation and cyanation of aldehydes.Science advances · 2023Article
- Novel practical stereoselective synthesis of a bicyclic hydantoino-thiolactone as the key intermediate for production of (+)-biotin.RSC advances · 2023Article
- Recent Advances in the Enantioselective Radical Reactions.Molecules (Basel, Switzerland) · 2023Review
- Copper-catalyzed asymmetric C(spNature communications · 2023Article
- New insights into the mechanism of synergetic photoredox/copper(i)-catalyzed carbocyanation of 1,3-dienes: a DFT study.Chemical science · 2023Article
- Expanding Reaction Profile of Allyl Carboxylates via 1,2-Radical Migration (RaM): Visible-Light-Induced Phosphine-Catalyzed 1,3-Carbobromination of Allyl Carboxylates.Journal of the American Chemical Society · 2023Article
- Article
- Effects of the Chalcogenide Identity inChemCatChem · 2022Article
- Intermolecular Photocatalytic Chemo-, Stereo- and Regioselective Thiol-Yne-Ene Coupling Reaction.Angewandte Chemie (International ed. in English) · 2022Article
- α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes.Chemical science · 2022Article
- Metal-free, visible-light induced enantioselective three-component dicarbofunctionalization and oxytrifluoromethylation of enaminesChemical science · 2022Article
- Photoinduced 1,2-dicarbofunctionalization of alkenes with organotrifluoroborate nucleophilesChemical science · 2021Article
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Authors and funding
6 authors.
Funding
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Abstract
The intermolecular three-component alkene vicinal dicarbofunctionalization (DCF) reaction allows installation of two different carbon fragments. Despite extensive investigation into its ionic chemistry, the enantioseletive radical-mediated versions of DCF reactions remain largely unexplored. Herein, we report an intermolecular, enantioselective three-component radical vicinal dicarbofunctionalization reaction of olefins enabled by merger of radical addition and cross-coupling using photoredox and copper dual catalysis. Key to the success of this protocol relies on chemoselective addition of acyl and cyanoalkyl radicals, generated in situ from the redox-active oxime esters by a photocatalytic N-centered iminyl radical-triggered C-C bond cleavage event, onto the alkenes to form new carbon radicals. Single electron metalation of such newly formed carbon radicals to TMSCN-derived L1Cu(II)(CN)
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