Evidence map›Paper›PMID 33753551›Full record

ArticleMolecular cancer research : MCR2021

AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer.

Anna C Beck, Edward Cho, Jeffrey R White, Lily Paemka, Tiandao Li, Vivian W Gu, Dakota T Thompson, Kelsey E Koch, Christopher Franke, Matthew Gosse and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 2 countries.

Anna C BeckDepartment of Surgery, University of Iowa, Iowa City, Iowa.ORCID 0000-0003-0592-9540
Edward ChoDepartment of Surgery, University of Iowa, Iowa City, Iowa.
Jeffrey R WhiteDepartment of Surgery, University of Iowa, Iowa City, Iowa.
Lily PaemkaDepartment of Surgery, University of Iowa, Iowa City, Iowa.ORCID 0000-0001-7498-520X
Tiandao LiDepartment of Surgery, University of Iowa, Iowa City, Iowa.ORCID 0000-0003-1650-0555
Vivian W GuDepartment of Surgery, University of Iowa, Iowa City, Iowa.ORCID 0000-0002-8019-8998
Dakota T ThompsonDepartment of Surgery, University of Iowa, Iowa City, Iowa.ORCID 0000-0001-6313-4880
Kelsey E KochDepartment of Surgery, University of Iowa, Iowa City, Iowa.ORCID 0000-0001-9956-7688
Christopher FrankeDepartment of Surgery, University of Iowa, Iowa City, Iowa.
Matthew GosseDepartment of Pathology, University of Iowa, Iowa City, Iowa.ORCID 0000-0002-4041-4166
Vincent T WuDepartment of Surgery, University of Iowa, Iowa City, Iowa.
Shannon R LandersDepartment of Surgery, University of Iowa, Iowa City, Iowa.
Anthony J PamatmatDepartment of Surgery, University of Iowa, Iowa City, Iowa.ORCID 0000-0003-4652-8444
Mikhail V KulakDepartment of Surgery, University of Iowa, Iowa City, Iowa.
Ronald J WeigelDepartment of Surgery, University of Iowa, Iowa City, Iowa. ronald-weigel@uiowa.edu.
University of Iowa · US

Funding

University of Iowa Surgical Oncology Training GrantT32CA148062 · NCI · UNIVERSITY OF IOWA · PI WEIGEL, RONALD J · 2010 to 2020
$3.8M
RET as a novel therapeutic target for breast cancerR01CA183702 · NCI · UNIVERSITY OF IOWA · PI WEIGEL, RONALD J · 2015 to 2019
$1.7M
NCI NIH HHS R01 CA183702NCI NIH HHS T32 CA148062
6 · The paper itself

Abstract

Activating protein 2 alpha (AP-2α; encoded by

Indexed as

AminopyridinesAnimalsBiomarkers, TumorCell Line, TumorCell SurvivalColonic NeoplasmsGene Expression ProfilingGene Expression Regulation, NeoplasticGene Knockout TechniquesHCT116 CellsHumansMiceMorpholinesPhosphoinositide-3 Kinase InhibitorsRNA InterferenceRNA-SeqAminopyridinesBiomarkers, TumorMorpholinesNVP-BKM120Phosphoinositide-3 Kinase InhibitorsTFAP2A protein, humanTranscription Factor AP-2

Identifiers

PMID33753551
PMCPMC8254761
OpenAlexW3137457172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.