Evidence map›Paper›PMID 33753519›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Selective cysteine-to-selenocysteine changes in a [NiFe]-hydrogenase confirm a special position for catalysis and oxygen tolerance.

Rhiannon M Evans, Natalie Krahn, Bonnie J Murphy, Harrison Lee, Fraser A Armstrong, Dieter Söll

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Lessons, connections, hypotheses and predictions from protein film electrochemistry.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  3. Frontiers in microbiology · 2026
    Article
  4. Methanogenic archaea encoding Pyrrolysine maintain ambiguous amber codon usage.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Tuning tRNAs for improved translation.Frontiers in genetics · 2024
    Review
  11. Article
  12. Biosynthesis, Engineering, and Delivery of Selenoproteins.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Unconventional genetic code systems in archaea.Frontiers in microbiology · 2022
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rhiannon M EvansInorganic Chemistry Laboratory, University of Oxford, Oxford OX1 3QR, United Kingdom.ORCID 0000-0002-9549-4220
Natalie KrahnDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511.ORCID 0000-0003-0696-433X
Bonnie J MurphyInorganic Chemistry Laboratory, University of Oxford, Oxford OX1 3QR, United Kingdom.ORCID 0000-0001-6341-9368
Harrison LeeInorganic Chemistry Laboratory, University of Oxford, Oxford OX1 3QR, United Kingdom.
Fraser A ArmstrongInorganic Chemistry Laboratory, University of Oxford, Oxford OX1 3QR, United Kingdom; fraser.armstrong@chem.ox.ac.uk dieter.soll@yale.edu.ORCID 0000-0001-8041-2491
Dieter SöllDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511; fraser.armstrong@chem.ox.ac.uk dieter.soll@yale.edu.ORCID 0000-0002-3077-8986

Funding

Studies of Transfer RNAR35GM122560 · NIGMS · YALE UNIVERSITY · PI SOLL, DIETER · 2017 to 2022
$5.6M
Biotechnology and Biological Sciences Research Council BB/I022309-1Biotechnology and Biological Sciences Research Council BB/L009722/1NIGMS NIH HHS R35 GM122560
6 · The paper itself

Abstract

In [NiFe]-hydrogenases, the active-site Ni is coordinated by four cysteine-S ligands (Cys; C), two of which are bridging to the Fe(CO)(CN)

Indexed as

Amino Acid SubstitutionBiocatalysisCysteineEscherichia coli ProteinsHydrogenaseOxygenSelenocysteineCysteineEscherichia coli ProteinsHydrogenasehydrogenase 1, E colinickel-iron hydrogenaseOxygenSelenocysteinehydrogen activationhydrogenaseoxygen toleranceselenocysteine

Identifiers

PMID33753519
PMCPMC8020662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.