ArticleProceedings of the National Academy of Sciences of the United States of America2021
Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 102 citations in OpenAlex.
- Article
- Hyperpolarised magnetic resonance spectroscopy with lab-on-a-chip disease models.Disease models & mechanisms · 2026Review
- Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI.Journal of magnetic resonance imaging : JMRI · 2026Review
- Nuclear spin hyperpolarization of pyruvate enables longitudinal monitoring of treatment response in intestinal tumor organoids.Magnetic resonance in medicine · 2025Article
- Improving the Catalyst Efficiency for Hyperpolarization of Pyruvate Derivatives by Means of Hydrogenative PHIP.ChemMedChem · 2025Article
- Tailoring rhodium-based metal-organic layers for parahydrogen-induced polarization: achieving 20% polarization ofNational science review · 2025Article
- Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications.Analysis & sensing · 2025Article
- Enhancing Sensitivity of Nuclear Magnetic Resonance in Biomolecules: Parahydrogen-Induced Hyperpolarization in Synthetic Disulfide-Rich Miniproteins.Journal of the American Chemical Society · 2024Article
- Yeast Solutions and Hyperpolarization Enable Real-Time Observation of Metabolized Substrates Even at Natural Abundance.Analytical chemistry · 2024Article
- Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer.Communications chemistry · 2024Article
- Live magnetic observation of parahydrogen hyperpolarization dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Parahydrogen-enhanced pH measurements using [1-The Analyst · 2024Article
- Robust parahydrogen-induced polarization at high concentrations.Science advances · 2024Article
- Enhanced Solubility and Polarization ofACS applied materials & interfaces · 2024Article
- Long-lived enhanced magnetization-A practical metabolic MRI contrast material.Science advances · 2024Article
- Efficient Parahydrogen-InducedJournal of the American Chemical Society · 2024Article
- Molecules, Up Your Spins!Molecules (Basel, Switzerland) · 2024Article
- Enzymatic Reactions Observed with Zero- and Low-Field Nuclear Magnetic Resonance.Analytical chemistry · 2023Article
- Parahydrogen-induced polarization enables the single-scan NMR detection of a 236 kDa biopolymer at nanomolar concentrations.Scientific reports · 2023Article
- Imaging immunomodulatory treatment responses in a multiple sclerosis mouse model using hyperpolarizedCommunications medicine · 2023Article
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Authors and funding
17 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperpolarized fumarate is a promising biosensor for carbon-13 magnetic resonance metabolic imaging. Such molecular imaging applications require nuclear hyperpolarization to attain sufficient signal strength. Dissolution dynamic nuclear polarization is the current state-of-the-art methodology for hyperpolarizing fumarate, but this is expensive and relatively slow. Alternatively, this important biomolecule can be hyperpolarized in a cheap and convenient manner using parahydrogen-induced polarization. However, this process requires a chemical reaction, and the resulting solutions are contaminated with the catalyst, unreacted reagents, and reaction side-product molecules, and are hence unsuitable for use in vivo. In this work we show that the hyperpolarized fumarate can be purified from these contaminants by acid precipitation as a pure solid, and later redissolved to a desired concentration in a clean aqueous solvent. Significant advances in the reaction conditions and reactor equipment allow for formation of hyperpolarized fumarate at
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