Evidence map›Paper›PMID 33753509›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

PPARγ marks splenic precursors of multiple nonlymphoid-tissue Treg compartments.

Chaoran Li, Andrés R Muñoz-Rojas, Gang Wang, Alexander O Mann, Christophe Benoist, Diane Mathis

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. T-betThe FEBS journal · 2026
    Article
  3. Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Biomedical reports · 2024
    Article
  11. An integrated transcription factor framework for Treg identity and diversity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chaoran LiDepartment of Immunology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-8103-9596
Andrés R Muñoz-RojasDepartment of Immunology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-1251-723X
Gang WangDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Alexander O MannDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA 02115 dm@hms.harvard.edu.
Harvard University · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
Adipose-tissue Tregs: important players in immunological control of metabolismR01DK092541 · NIDDK · HARVARD MEDICAL SCHOOL · PI DIANE J MATHIS · 2011 to 2026
$6.4M
Special BD LSRFortessaS10OD021740 · OD · JOSLIN DIABETES CENTER · PI SERWOLD, THOMAS F · 2016 to 2016
$363k
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK092541NIH HHS S10 OD021740
6 · The paper itself

Abstract

Foxp3

Indexed as

TranscriptomeAdoptive TransferAnimalsIntra-Abdominal FatMaleMiceMice, Inbred C57BLPPAR alphaRNA-SeqSingle-Cell AnalysisSpleenT-Lymphocytes, RegulatoryPPAR alphaPpara protein, mouseimmunoregulationprecursorsingle-cell RNA-seqtissue Treg cell

Identifiers

PMID33753509
PMCPMC8020779
OpenAlexW3138653680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.