Evidence map›Paper›PMID 33753505›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Evolved increases in hemoglobin-oxygen affinity and the Bohr effect coincided with the aquatic specialization of penguins.

Anthony V Signore, Michael S Tift, Federico G Hoffmann, Todd L Schmitt, Hideaki Moriyama, Jay F Storz

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Blood oxygen transport and depletion in diving emperor penguins.The Journal of experimental biology · 2024
    Article
  5. Article
  6. Article
  7. Energetic Lifestyle Drives Size and Shape of Avian Erythrocytes.Integrative and comparative biology · 2022
    Article
  8. Article
  9. Allosteric regulation of substrate channeling:Frontiers in molecular biosciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anthony V SignoreSchool of Biological Sciences, University of Nebraska, Lincoln, NE 68588; anthony.signore@unl.edu.ORCID 0000-0002-0664-0864
Michael S TiftDepartment of Biology and Marine Biology, University of North Carolina, Wilmington, NC 28403.
Federico G HoffmannDepartment of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, Starkville, MS 39762.ORCID 0000-0001-5056-4929
Todd L SchmittVeterinary Services, SeaWorld of California, San Diego, CA 92109.ORCID 0000-0001-7703-1540
Hideaki MoriyamaSchool of Biological Sciences, University of Nebraska, Lincoln, NE 68588.ORCID 0000-0001-7815-1181
Jay F StorzSchool of Biological Sciences, University of Nebraska, Lincoln, NE 68588.ORCID 0000-0001-5448-7924

Funding

Mutational Pleiotropy, Epistasis, and the Adaptive Evolution of Hemoglobin FunctionR01HL087216 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI STORZ, JAY · 2008 to 2021
$4.5M
Identifying protective roles of the heme oxygenase/carbon monoxide pathway in hypoxia-tolerant model systemsF32HL136202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TIFT, MICHAEL · 2017 to 2018
$84k
NHLBI NIH HHS F32 HL136202NHLBI NIH HHS R01 HL087216
6 · The paper itself

Abstract

Dive capacities of air-breathing vertebrates are dictated by onboard O

Indexed as

Adaptation, PhysiologicalAmino Acid SubstitutionAnimalsOxygenOxyhemoglobinsPhylogenyProtein ConformationProtein EngineeringSpheniscidaeOxygenOxyhemoglobinsadaptationBohr effecthemoglobinhypoxiapenguins

Identifiers

PMID33753505
PMCPMC8020755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.