Evidence map›Paper›PMID 33753483›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

ICOS ligand and IL-10 synergize to promote host-microbiota mutualism.

Ashley E Landuyt, Barbara J Klocke, Lennard W Duck, Keri M Kemp, Rachel Q Muir, Melissa S Jennings, Samuel I Blum, Hubert M Tse, Goo Lee, Casey D Morrow and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Virulence · 2024
    Review
  7. Article
  8. The Underappreciated Role of Secretory IgA in IBD.Inflammatory bowel diseases · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ashley E LanduytDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.
Barbara J KlockeDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.
Lennard W DuckDivision of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.
Keri M KempDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0003-3538-852X
Rachel Q MuirDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0002-7671-0776
Melissa S JenningsDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0002-6814-8525
Samuel I BlumDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0002-8171-2901
Hubert M TseDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294.
Goo LeeDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0003-3025-5234
Casey D MorrowDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294.
Charles O ElsonDivision of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0001-8873-1534
Craig L MaynardDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294; craigmaynard@uabmc.edu.ORCID 0000-0001-5876-8168
University of Alabama at Birmingham · US

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1M
Mentored Experiences in Research, Instruction and Teaching (MERIT) Program - administrative supplementK12GM088010 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2009 to 2024
$9.2M
UAB Skin Diseases Research CenterP30AR050948 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEDISHVILI, NATALIA Y · 2004 to 2013
$5.5M
T Cell Co-stimulation and the Resistance of Regulatory T cells to Gut InflammationR21DK118386 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MAYNARD, CRAIG L · 2019 to 2021
$557k
NCATS NIH HHS UL1 TR001417NIAID NIH HHS T32 AI007051NIAMS NIH HHS P30 AR050948NIDDK NIH HHS R21 DK118386NIGMS NIH HHS K12 GM088010
6 · The paper itself

Abstract

Genome-wide association studies have identified

Indexed as

AnimalsAntibodies, BacterialAntigens, BacterialCD4-Positive T-LymphocytesColonDisease Models, AnimalFemaleGastrointestinal MicrobiomeHost Microbial InteractionsHumansInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinInflammatory Bowel DiseasesInterleukin-10Intestinal MucosaMaleAntibodies, BacterialAntigens, BacterialIcosl protein, mouseIcos protein, mouseIL10 protein, mouseInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinInterleukin-10anti-commensal antibodiesICOSLIL-10microbiota

Identifiers

PMID33753483
PMCPMC8020652
OpenAlexW3139434679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.