Evidence map›Paper›PMID 33753336›Full record

ArticleAntimicrobial agents and chemotherapy2021

Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms.

Mark C Butcher, Jason L Brown, Donald Hansom, Rebecca Wilson-van Os, Craig Delury, Phillip A Laycock, Gordon Ramage

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mark C ButcherOral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Jason L BrownOral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-8168-5333
Donald HansomOral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Rebecca Wilson-van OsBiocomposites, Ltd., Keele, Staffordshire, United Kingdom.
Craig DeluryBiocomposites, Ltd., Keele, Staffordshire, United Kingdom.
Phillip A LaycockBiocomposites, Ltd., Keele, Staffordshire, United Kingdom.
Gordon RamageOral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom gordon.ramage@glasgow.ac.uk.ORCID 0000-0002-0932-3514

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium sulfate (CS) has been used clinically as a bone- or void-filling biomaterial, and its resorptive properties have provided the prospect for its use as a release mechanism for local antibiotics to control biofilms. Here, we aimed to test CS beads loaded with three antifungal drugs against planktonic and sessile fungal species to assess whether these antifungal beads could be harnessed to provide consistent release of antifungals at biofilm-inhibitory doses. A panel of different fungal species (

Indexed as

Antifungal AgentsCalcium SulfateBiofilmsFluconazoleMicrobial Sensitivity TestsAntifungal AgentsCalcium SulfateFluconazoleantimicrobial agentsbiofilmCandidafungaljoint infectionswound management

Identifiers

PMID33753336
PMCPMC8316021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.