ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2021
Exercise right ventricular ejection fraction predicts right ventricular contractile reserve.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Exercise testing for evaluating right ventricular (RV) function in pulmonary hypertension - A review.Lung India : official organ of Indian Chest Society · 2026Article
- Advancement in pre- and peri-procedural imaging.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Exercise haemodynamics in pulmonary hypertension - a prospective pressure-volume loop study on right ventricular adaptation and prognosis.European journal of heart failure · 2025Article
- Diagnostic value of heart rate-based methods for assessing cardiac autonomic neuropathy in prediabetes and diabetes.Physiological reports · 2025Article
- A Word of Caution-Potential Limitations of Pulmonary Artery Pressure Monitoring in Detecting Congestion Caused by Right-Sided Heart Failure.Biomedicines · 2025Article
- Cellular Communication Network Protein 2 in the Right Ventricle of Pulmonary Arterial Hypertension.Pulmonary circulation · 2025Article
- Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series).Pulmonary circulation · 2025Article
- An Unsupervised Approach to Derive Right Ventricular Pressure-Volume Loop Phenotypes in Pulmonary Hypertension.Pulmonary circulation · 2025Article
- Non-invasive surrogates for right Ventricular-Pulmonary arterial coupling: a systematic review and Meta-Analysis.Pulmonary circulation · 2024Article
- Poor cardiac output reserve in pulmonary arterial hypertension is associated with right ventricular stiffness and impaired interventricular dependence.The European respiratory journal · 2024Article
- Physiological mechanisms behind respiratory variations in right atrial pressure in pulmonary hypertension.Scientific reports · 2024Observational
- Occult right ventricular dysfunction and right ventricular-vascular uncoupling in left ventricular assist device recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function.European journal of heart failure · 2024Article
- Foreword.Interventional cardiology (London, England) · 2024Article
- Review
- Role of Exercise Stress Echocardiography in Pulmonary Hypertension.Life (Basel, Switzerland) · 2023Review
- Metabolic profiling of in vivo right ventricular function and exercise performance in pulmonary arterial hypertension.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- The Acute Effects of Prostacyclin on Right Ventricular Contractility and Pulmonary Artery Coupling.American journal of respiratory and critical care medicine · 2023Article
- Are you Coupled? Hemodynamic Phenotyping in Pulmonary Hypertension.Function (Oxford, England) · 2022Article
- Hemodynamics for the Heart Failure Clinician: A State-of-the-Art Review.Journal of cardiac failure · 2022Review
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRight ventricular (RV) contractile reserve shows promise as an indicator of occult RV dysfunction in pulmonary vascular disease. We investigated which measure of RV contractile reserve during exercise best predicts occult RV dysfunction and clinical outcomes.
methodsWe prospectively studied RV contractile reserve in 35 human subjects referred for right heart catheterization for known or suspected pulmonary hypertension. All underwent cardiac magnetic resonance imaging, echocardiography, and supine invasive cardiopulmonary exercise testing with concomitant RV pressure-volume catheterization. Event-free survival was prospectively adjudicated from time of right heart catheterization for a 4-year follow-up period.
resultsRV contractile reserve during exercise, as measured by a positive change in end-systolic elastance (Ees) during exertion, was associated with elevation in pulmonary pressures but preservation of RV volumes. Lack of RV reserve, on the other hand, was tightly coupled with acute RV dilation during exertion (R
conclusionsRV ejection fraction during exercise, as an index of RV contractile reserve, allows for excellent identification of occult RV dysfunction, more so than resting measures of RV function, and may predict clinical outcomes as well.
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Registered trials
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