Evidence map›Paper›PMID 33752880›Full record

ArticleFertility and sterility2021

Duration, recency, and type of hormonal contraceptive use and antimüllerian hormone levels.

Lia A Bernardi, Marissa Steinberg Weiss, Anne Waldo, Quaker Harmon, Mercedes R Carnethon, Donna D Baird, Lauren A Wise, Erica E Marsh

Abstract readComparative Study
In one paragraph

Article in Fertility and sterility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Lia A BernardiDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Marissa Steinberg WeissDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
Anne WaldoDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
Quaker HarmonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Mercedes R CarnethonDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Donna D BairdEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
Erica E MarshDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan. Electronic address: marshee@med.umich.edu.

Funding

Uterine LeiomyomasZIAES049013 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JUKIC, ANNE MARIE · 2009 to 2025
$14.7M
Environmental Effects On FertilityZIAES049003 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BAIRD, DONNA D. · 2009 to 2023
$3.3M
Study of Ovarian Aging and Reserve in Young Women (SOAR)R01HD088638 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARSH, ERICA E · 2017 to 2022
$3.1M
Intramural NIH HHS ZIA ES049013NICHD NIH HHS R01 HD088638
6 · The paper itself

Abstract

objectiveTo assess whether the duration, recency, or type of hormonal contraceptive used is associated with antimüllerian hormone (AMH) levels, given that the existing literature regarding the association between hormonal contraceptive use and AMH levels is inconsistent.

designCross-sectional study.

settingBaseline data from the Study of the Environment, Lifestyle and Fibroids Study, a 5-year longitudinal study of African American women. PATIENT(S): The patients were 1,643 African American women aged 23-35 years at the time of blood drawing (2010-2012). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Serum AMH level was measured by an ultrasensitive enzyme-linked immunosorbent assay. Linear regression models were used to estimate percent differences in mean AMH levels and 95% confidence intervals (CIs) according to use of hormonal contraceptives, with adjustment for potential confounders. RESULT(S): In multivariable-adjusted analyses, current users of hormonal contraceptives had 25.2% lower mean AMH levels than non-users of hormonal contraceptives (95% CI: -35.3%, -13.6%). There was little difference in AMH levels between former users and non-users of hormonal contraceptives (-4.4%; 95% CI: -16.3%, 9.0%). AMH levels were not appreciably associated with cumulative duration of use among former users or time since last use among non-current users. Current users of combined oral contraceptives (-24.0%; 95% CI: -36.6%, -8.9%), vaginal ring (-64.8%; 95% CI: -75.4%, -49.6%), and depot medroxyprogesterone acetate (-26.7%; 95% CI: -41.0%, -8.9%) had lower mean AMH levels than non-users. CONCLUSION(S): The present data suggest that AMH levels are significantly lower among current users of most forms of hormonal contraceptives, but that the suppressive effect of hormonal contraceptives on AMH levels is reversible.

Indexed as

AdultAnti-Mullerian HormoneBiomarkersBlack or African AmericanContraceptive Agents, HormonalContraceptives, Oral, HormonalCross-Sectional StudiesDown-RegulationDrug Administration ScheduleDuration of TherapyEnzyme-Linked Immunosorbent AssayFemaleHumansTime FactorsYoung AdultAnti-Mullerian HormoneBiomarkersContraceptive Agents, HormonalContraceptives, Oral, HormonalAntimüllerian hormonehormonal contraceptivesovarian reserve

Identifiers

PMID33752880
PMCPMC8217153

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.