Evidence map›Paper›PMID 33752824›Full record

ReviewVitamins and hormones2021

Nuclear receptors linking physiology and germline stem cells in Drosophila.

Danielle S Finger, Kaitlin M Whitehead, Daniel N Phipps, Elizabeth T Ables

Open access · greenAbstract readReview
In one paragraph

Review in Vitamins and hormones, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Chromium-histidine complex enhances reproductive physiology and development in Drosophila melanogaster by modulating oxidative stress.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
  2. Article
  3. Article
  4. A high-throughput method for quantifyingbioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Chili-supplemented food decreases glutathione-Redox report : communications in free radical research · 2022
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Danielle S FingerDepartment of Biology, East Carolina University, Greenville, NC, United States.
Kaitlin M WhiteheadDepartment of Biology, East Carolina University, Greenville, NC, United States.
Daniel N PhippsDepartment of Biology, East Carolina University, Greenville, NC, United States.
Elizabeth T AblesDepartment of Biology, East Carolina University, Greenville, NC, United States. Electronic address: ablese@ecu.edu.
East Carolina University · US

Funding

Molecular mechanisms of oocyte development in DrosophilaR15GM117502 · NIGMS · EAST CAROLINA UNIVERSITY · PI ABLES, ELIZABETH TWEEDIE · 2016 to 2023
$1.4M
NIGMS NIH HHS R15 GM117502
6 · The paper itself

Abstract

Maternal nutrition and physiology are intimately associated with reproductive success in diverse organisms. Despite decades of study, the molecular mechanisms linking maternal diet to the production and quality of oocytes remain poorly defined. Nuclear receptors (NRs) link nutritional signals to cellular responses and are essential for oocyte development. The fruit fly, Drosophila melanogaster, is an excellent genetically tractable model to study the relationship between NR signaling and oocyte production. In this review, we explore how NRs in Drosophila regulate the earliest stages of oocyte development. Long-recognized as an essential mediator of developmental transitions, we focus on the intrinsic roles of the Ecdysone Receptor and its ligand, ecdysone, in oogenesis. We also review recent studies suggesting broader roles for NRs as regulators of maternal physiology and their impact specifically on oocyte production. We propose that NRs form the molecular basis of a broad physiological surveillance network linking maternal diet with oocyte production. Given the functional conservation between Drosophila and humans, continued experimental investigation into the molecular mechanisms by which NRs promote oogenesis will likely aid our understanding of human fertility.

Indexed as

Drosophila melanogasterDrosophila ProteinsOogenesisReceptors, SteroidAnimalsGerm CellsStem CellsDrosophila Proteinsecdysone receptorReceptors, SteroidDrosophilaEcdysoneEcREip74EFEip75BEip78CGerm cellNuclear hormone receptorOocyteOogenesisSteroid hormoneUsp

Identifiers

PMID33752824
PMCPMC8063499
OpenAlexW3137827723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.