ArticleeLife2021
Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- A systematic review and meta-analysis of blood level of MCP-1/CCL-2 in severe and uncomplicated malaria.Scientific reports · 2024Pooled it
- The impact of innate immunity on malaria parasite infection dynamics in rodent models.Frontiers in immunology · 2023Pooled it
- Article
- The case for exploring innate memory in Plasmodium infection.Current opinion in microbiology · 2026Review
- Unmasking Malaria: Microscopy and nPCR Reveal the Hidden Misdiagnosis ofInterdisciplinary perspectives on infectious diseases · 2026Article
- Review
- Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection.Nature communications · 2025Article
- Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.The Journal of experimental medicine · 2025Article
- STAT Signature Dish: Serving Immunity with a Side of Dietary Control.Biomolecules · 2025Review
- Morphometric analysis and immunobiological investigation ofOpen life sciences · 2025Article
- The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria.Nature reviews. Immunology · 2024Review
- Targeting circulating labile heme as a defense strategy against malaria.Life science alliance · 2024Article
- Monocytes as Targets for Immunomodulation by Regional Citrate Anticoagulation.International journal of molecular sciences · 2024Article
- Editorial: Immune tolerance and human malaria.Frontiers in immunology · 2024Article
- scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets.Nature communications · 2023Article
- A systematic analysis of the human immune response to Plasmodium vivax.The Journal of clinical investigation · 2023Article
- STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria.The Journal of clinical investigation · 2023Article
- Cellular iron governs the host response to malaria.PLoS pathogens · 2023Article
- The characterization of toll-like receptor repertoire inEcology and evolution · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Immunity to malaria is often considered slow to develop but this only applies to defense mechanisms that function to eliminate parasites (resistance). In contrast, immunity to severe disease can be acquired quickly and without the need for improved pathogen control (tolerance). Using
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.