Trial reportBMC health services research2021
Improved adherence with Medicines Use Review service in Slovenia: a randomized controlled trial.
Trial report in BMC health services research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04417400 (Benefits of Medicines Use Review Service in Slovenia), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Benefits of Medicines Use Review Service in Slovenia: a Randomized Controlled Trial
Who cites it
5 citing papers in PubMed.
- Evolution of community pharmacy services in the European Union and beyond: a cross-country survey of 33 national pharmacy organisations.International journal of clinical pharmacy · 2026Article
- Review
- Enhancing Glycaemic Control and Diabetes Self-care Behaviours through a Standardised Pharmacist-led Service: Evidence from Community Pharmacies in Southeastern Serbia.Zdravstveno varstvo · 2025Article
- The Arabic medication-related burden quality of life (MRB-QoL) tool: Cross-cultural adaptation and content validation.Exploratory research in clinical and social pharmacy · 2024Article
- Assessment of Pharmacists' Willingness to Conduct Medication Use Reviews in Poland.International journal of environmental research and public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundBased on several existing patient-oriented activities, Medicines Use Review (MUR) service was standardized and officially adopted in Slovenia in 2015. Service aims to provide adherence support and ensure safe and effective medicines use. Therefore, the aim of the study was to evaluate the benefits of MUR in Slovenia, primarily the impact on medication adherence.
methodsA randomised controlled trial was performed in community pharmacies to compare MUR with standard care. Patients were randomised into either the test (patients received MUR by a certified MUR provider at visit 1), or control group. The study primary outcome was self-reported adherence to multiple medications, assessed by electronic ©Morisky Widget MMAS-8 Software at the first visit (V1) and after 12 weeks (V2). A sub-analysis of intentional and unintentional non-adherence was performed. MUR impact was defined as the relative difference in ©MMAS-8 score after 12 weeks between the test and control group. A multiple linear regression model was used to predict MUR impact based on baseline adherence (low versus medium and high). Several secondary outcomes (e.g. evaluation of drug-related problems (DRPs)) were also assessed.
resultsData from 153 (V1) and 140 (V2) patients were analysed. Baseline adherence was low, moderate and high in 17.6, 48.4 and 34.0% patients, respectively. In the low adherence subpopulation, test group patients showed a 1.20 point (95% CI = 0.16-2.25) increase in total ©MMAS-8 score (p = 0.025) compared to control group patients. A 0.84 point (95% CI = 0.05-1.63) increase was due to intentional non-adherence (p = 0.038), and a 0.36 point (95% CI = - 0.23-0.95) was due to unintentional non-adherence (p = 0.226). Additionally, statistically significant decrease in the proportion of patients with manifested DRPs (p < 0.001) and concerns regarding chronic medicines use (p = 0.029) were revealed.
conclusionMUR service in Slovenia improves low medication adherence and is effective in addressing DRPs and concerns regarding chronic medicines use.
trial registrationClinicalTrials.gov - NCT04417400 ; 4th June 2020; retrospectively registered.
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