ArticleBMC infectious diseases2021
Physical disabilities caused by leprosy in 100 million cohort in Brazil.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Disability as a neglected outcome of neglected tropical diseases: A systematic review.PLoS neglected tropical diseases · 2026Pooled it
- On the usage of artificial intelligence in leprosy care: A systematic literature review.PLoS computational biology · 2025Pooled it
- Temporal trend and factors associated with physical disability due to leprosyl: a time series study, Brazil, 2014-2023.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2026Article
- Economic cost of Hansen's disease: an overview of social security expenditures.Frontiers in public health · 2026Article
- Evaluating Machine Learning Models for Predicting Late Leprosy Diagnosis by Physical Disability Grade in Brazil (2018-2022).Tropical medicine and infectious disease · 2025Article
- Time trend and identification of risk areas for physical disability due to leprosy in Brazil: An ecological study, 2001-2022.BMC infectious diseases · 2025Article
- Participatory development of Indonesia's national action plan for zero leprosy: strategies and interventions.Frontiers in public health · 2025Article
- Epidemiological, clinical, and geographical characterization of Leprosy in the County of Santarém-Pará: Insights for effective control and targeted intervention.PLoS neglected tropical diseases · 2024Article
- Profile of the leprosy endemic in the district of Murrupula, Nampula, Mozambique: A population-based study.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Clinical-epidemiological characteristics and temporal trend of new cases of grade 2 disability leprosy in the state of Maranhão, Brazil, 2011- 2020.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2023Article
- Clusters of risk for the occurrence of leprosy and disabilities in children under 15 years of age in Cuiabá: a geospatial study.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2023Article
- Cohort Profile: The 100 Million Brazilian Cohort.International journal of epidemiology · 2022Article
- Leprosy and cutaneous leishmaniasis affecting the same individuals: A retrospective cohort analysis in a hyperendemic area in Brazil.PLoS neglected tropical diseases · 2021Article
- Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.PLoS neglected tropical diseases · 2021Observational
- Disability among Leprosy Patients in the Lustrum 2016-2020: Retrospective Study from a Tertiary Care Centre in Southern Kerala.Indian journal of dermatologyArticle
- A review of nutrition in neuropathic pain of leprosy.Therapeutic advances in infectious diseaseReview
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundLeprosy continues to be an important cause of physical disability in endemic countries such as Brazil. Knowledge of determinants of these events may lead to better control measures and targeted interventions to mitigate its impact on affected individuals. This study investigated such factors among the most vulnerable portion of the Brazilian population.
methodsA large cohort was built from secondary data originated from a national registry of applicants to social benefit programs, covering the period 2001-2015, including over 114 million individuals. Data were linked to the leprosy notification system utilizing data from 2007 until 2014. Descriptive and bivariate analyses lead to a multivariate analysis using a multinomial logistic regression model with cluster-robust standard errors. Associations were reported as Odds Ratios with their respective 95% confidence intervals.
resultsAmong the original cohort members 21,565 new leprosy cases were identified between 2007 and 2014. Most of the cases (63.1%) had grade zero disability. Grades 1 and 2 represented 21 and 6%, respectively. Factors associated with increasing odds of grades 1 and 2 disability were age over 15 years old (ORs 2.39 and 1.95, respectively), less schooling (with a clear dose response effect) and being a multibacillary patient (ORs 3.5 and 8.22). Protective factors for both grades were being female (ORs 0.81 and 0.61) and living in a high incidence municipality (ORs 0.85 and 0.67).
conclusionsThe findings suggest that the developing of physical disabilities remains a public health problem which increases the burden of leprosy, mainly for those with severe clinical features and worse socioeconomic conditions. Early diagnosis is paramount to decrease the incidence of leprosy-related disability and our study points to the need for strengthening control actions in non-endemic areas in Brazil, where cases may be missed when presented at early stages in disease. Both actions are needed, to benefit patients and to achieve the WHO goal in reducing physical disabilities among new cases of leprosy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.