Evidence map›Paper›PMID 33752569›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents.

TaeHun Kim, Mohammad N Morshed, Ashwini M Londhe, Ji W Lim, Ha E Lee, Suengmok Cho, Sung J Cho, Hayoung Hwang, Sang M Lim, Jae Y Lee and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

TaeHun KimConvergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Mohammad N MorshedConvergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Ashwini M LondheConvergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Ji W LimConvergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Ha E LeeConvergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Suengmok ChoDepartment of Food Science and Technology, Pukyong National University, Pusan, Republic of Korea.ORCID https://orcid.org/0000-0001-5951-5832
Sung J ChoNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, Republic of Korea.
Hayoung HwangNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, Republic of Korea.
Sang M LimConvergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-0419-8950
Jae Y LeeConvergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Jiyoun LeeDepartment of Global Medical Science, Sungshin University, Seoul, Republic of Korea.
Ae N PaeConvergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Convergence Research Center for Diagnosis Treatment and Care System of Dementia · KRDaegu-Gyeongbuk Medical Innovation Foundation · KRKyung Hee University · KRSungshin Women's University · KRUniversity of Dhaka · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small molecule modulators of mitochondrial function have been attracted much attention in recent years due to their potential therapeutic applications for neurodegenerative diseases. The mitochondrial translocator protein (TSPO) is a promising target for such compounds, given its involvement in the formation of the mitochondrial permeability transition pore in response to mitochondrial stress. In this study, we performed a ligand-based pharmacophore design and virtual screening, and identified a potent hit compound,

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsCells, CulturedCell SurvivalDisease Models, AnimalDrug Evaluation, PreclinicalHumansLigandsMiceMitochondriaMolecular StructureNeuroprotective AgentsProtein Aggregation, PathologicalSmall Molecule LibrariesTranscriptional Regulator ERGAmyloid beta-PeptidesERG protein, humanLigandsNeuroprotective AgentsSmall Molecule LibrariesTranscriptional Regulator ERGAlzheimer’s diseasefunction modulatorstranslocator protein ligand

Identifiers

PMID33752569
PMCPMC7996082
OpenAlexW3137527447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.