Evidence map›Paper›PMID 33751818›Full record

ArticlePediatric blood & cancer2021

Adjustments to pharmacologic therapies for hemophagocytic lymphohistiocytosis while on extracorporeal support.

Angela C Weyand, Ryan P Barbaro, Kelly J Walkovich, David G Frame

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Angela C WeyandDepartment of Pediatrics, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-2595-8541
Ryan P BarbaroDepartment of Pediatrics, Division of Critical Care, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-3645-0359
Kelly J WalkovichDepartment of Pediatrics, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan, USA.
David G FrameDepartment of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan · US

Funding

Training to Advance Care Through Implementation Science in Cardiac And Lung Illnesses (TACTICAL)K12HL138039 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARNES, GEOFFREY DOUGLAS, PRESCOTT, HALLIE CHRISTINE · 2017 to 2021
$3.1M
NHLBI NIH HHS K12 HL138039
6 · The paper itself

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is an immune dysregulatory syndrome characterized by severe inflammation and end-organ damage. Due to significant organ dysfunction, patients often require extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT). In this report, we describe consideration for adjusting treatment in the context of extracorporeal organ support. We describe agents commonly used and dosing adjustments made in light of extracorporeal organ support. We report six cases that illustrate the feasibility of initiating standard HLH therapies in patients requiring these modalities.

Indexed as

Extracorporeal Membrane OxygenationAnti-Inflammatory AgentsChild, PreschoolContinuous Renal Replacement TherapyDexamethasoneEtoposideHumansInfantInfant, NewbornIntensive Care Units, PediatricLymphohistiocytosis, HemophagocyticRetrospective StudiesAnti-Inflammatory AgentsDexamethasoneEtoposidechemotherapycoagulationhemophagocytic lymphohistiocytosisinfectionsintensive carepharmacology

Identifiers

PMID33751818
PMCPMC8068609
OpenAlexW3134113945

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.