SynthesisHaemophilia : the official journal of the World Federation of Hemophilia2021
A systematic review of physical activity in people with haemophilia and its relationship with bleeding phenotype and treatment regimen.
Synthesis in Haemophilia : the official journal of the World Federation of Hemophilia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Measuring Physical Function Capacity in Persons With Haemophilia: A Systematic Review of Performance-Based Methods.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Pooled it
- Physical activity patterns in people with haemophilia with and without arthropathy: a cross-sectional study using wearable sensors.Thrombosis journal · 2026Article
- Article
- The relationship between joint health, kinesiophobia, physical activity level, and functional capacity in hemophilia patients: a case-control study.Acta orthopaedica et traumatologica turcica · 2026Article
- Final data from the German AHEAD study: effectiveness and safety of octocog alfa and rurioctocog alfa pegol for hemophilia A in a real-world setting.Therapeutic advances in hematology · 2026Article
- The VincerEmo Pilot Study: Prospective Analysis of Controlled Physical Activity in People with severe Hemophilia.Journal of clinical medicine · 2025Article
- Physical Activity Awareness and Understanding of Treatment Protection Among People With Haemophilia and Their Caregivers in Central Europe.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Article
- Spinal Stenosis: An Emerging Complication of Ageing in People With Haemophilia.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Article
- Development of a short form of the Swedish version of the Hemophilia Activities List.Scientific reports · 2025Article
- Subjective Physical Performance and Its Determinants in Patients With Haemophilia.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Article
- Teenagers and Adolescents with Hemophilia-Need for a Specific Approach.Journal of clinical medicine · 2024Review
- Physical Activity, Bleedings and Quality of Life in Subjects with Haemophilia A without Inhibitors-A Multicenter, Observational Italian Study with a Wearable Device.Journal of clinical medicine · 2024Article
- A Qualitative Study Exploring the Experiences and Perceptions of Patients with Hemophilia Regarding Their Health-Related Well-Being, in Salamanca.Journal of clinical medicine · 2023Article
- Sexual activity and the adolescent with haemophilia.Acta bio-medica : Atenei Parmensis · 2023Review
- Promoting physical activity for people with haemophilia in the age of new treatments.Haemophilia : the official journal of the World Federation of Hemophilia · 2022Review
- Thromboelastography and thrombin generation assessments for pediatric severe hemophilia A patients are highly variable and not predictive of clinical phenotypes.Research and practice in thrombosis and haemostasis · 2022Article
- Promoting physical activity in people with haemophilia: the MEMO (Movement for persons with haEMOphilia) expert consensus project.Blood transfusion = Trasfusione del sangue · 2022Article
- Exploration of the minimum necessary FVIII level at different physical activity levels in pediatric patients with hemophilia A.Frontiers in pediatrics · 2022Article
- Hemophilia Patient Experience in a Physical Therapy-Guided Health Education Intervention: A Mixed-Method Design.Healthcare (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionAlthough the measurement of physical activity (PA) amongst people with haemophilia (PWH) has become increasingly widespread in recent years, the relationship between PA and bleeding phenotype remains poorly understood. In addition, the influence of various treatment regimens on this relationship has not been defined.
aimThis review aimed to systematically assess the data that are available regarding PA levels amongst PWH, as well as the relationship between PA and bleeding.
methodsA systematic search of the online databases EMBASE, Cochrane, MEDLINE Ovid, CINAHL and Web of Science was conducted by two independent reviewers. Quality assessment was undertaken using the AXIS Critical Appraisal Tool for Cross-sectional Studies and the STROBE checklist.
resultsOf 1902 sources identified overall, 36 articles were included. Low-to-moderate transparency of reporting and various sources of bias were identified. PA levels varied amongst heterogeneous samples of PWH. The relationship between PA and bleeds was inconclusive, although there was evidence that improvements in treatment over recent decades have appeared to enable PWH to become more physically active.
conclusionBased upon the limited available evidence, the relationship between PA and bleeding phenotype in PWH remains unclear. However, with the development of improved prophylaxis treatment regimens in recent years, there is evidence that PA levels have increased, especially amongst people with severe haemophilia. The use of validated outcome measures of PA and more robust reporting of bleeds and treatment regimen are warranted in future research, especially in a rapidly evolving era of new treatments for PWH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.