Evidence map›Paper›PMID 33751333›Full record

ArticleInflammopharmacology2021

Diosmetin, a novel transient receptor potential vanilloid 1 antagonist, alleviates the UVB radiation-induced skin inflammation in mice.

Camila Camponogara, Evelyne S Brum, Natháli S Pegoraro, Indiara Brusco, Natália Brucker, Sara Marchesan Oliveira

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  6. Antioxidant and Anti-Inflammatory Effects of CrudeAntioxidants (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Camila CamponogaraLaboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Evelyne S BrumLaboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Natháli S PegoraroLaboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Indiara BruscoLaboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Natália BruckerGraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Sara Marchesan OliveiraLaboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. saramarchesan@hotmail.com.ORCID http://orcid.org/0000-0003-2960-5284
Universidade Federal de Santa Maria · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 307220/2017-6Conselho Nacional de Desenvolvimento Científico e Tecnológico 406098/2018-2Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior #88882.182152/2018-01Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 23038.005450/2020-19, Grant: #0578/2020Coordenação de Aperfeiçoamento de Pessoal de Nível Superior #88882.182128/2018-01Coordenação de Aperfeiçoamento de Pessoal de Nível Superior #88882.182148/2018-01Coordenação de Aperfeiçoamento de Pessoal de Nível Superior #88887.185973/2018-00Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 17/2551-0001082-5
6 · The paper itself

Abstract

UVB radiation-mediated inflammation and the oxidative process involve the transient receptor potential vanilloid 1 (TRPV1) channel activation in neuronal and non-neuronal cells. Once diosmetin has been identified as a novel TRPV1 antagonist, we evaluated the action of diosmetin from the inflammatory [ear oedema, myeloperoxidase (MPO) activity, histological changes, and cytokines levels] and oxidative [nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and SOD activities] parameters in mice exposed to UVB radiation (0.5 j/cm

Indexed as

AnimalsDose-Response Relationship, DrugFlavonoidsInflammationMaleMiceSkinSkin CreamSunburnTRPV Cation ChannelsUltraviolet RaysdiosmetinFlavonoidsTRPV1 protein, mouseTRPV Cation ChannelsDiosmetinOxidative stressResiniferatoxinSunburnTRP channelsUltraviolet radiation

Identifiers

PMID33751333
OpenAlexW3139382960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.