Evidence map›Paper›PMID 33751222›Full record

ArticleVirchows Archiv : an international journal of pathology2021

A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis.

Taro Murakami, Akira Takasawa, Asako Moriki, Yusuke Igaki, Hiroshi Ikeda, Kazuyuki Murase, Kohichi Takada, Kazufumi Magara, Tomoyuki Aoyama, Yusuke Ono and 4 more

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Taro MurakamiDepartment of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Akira TakasawaDepartment of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan. atakasawa@sapmed.ac.jp.ORCID http://orcid.org/0000-0002-3244-1199
Asako MorikiDepartment of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Yusuke IgakiDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Hiroshi IkedaDepartment of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Kazuyuki MuraseDepartment of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Kohichi TakadaDepartment of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Kazufumi MagaraDepartment of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Tomoyuki AoyamaDepartment of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Yusuke OnoDepartment of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Daisuke KyunoDepartment of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Kumi TakasawaDepartment of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Masaki MurataDepartment of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Makoto OsanaiDepartment of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Sapporo Medical University · JP

Funding

Japan Society for the Promotion of Science JP19K16561Japan Society for the Promotion of Science JP20K16196
6 · The paper itself

Abstract

Amyloidosis is induced by extracellular deposition of certain proteins. Thirty-six proteins have so far been identified as amyloidogenic proteins in humans. Although it is very important to determine the specific amyloid protein type for the choice of therapy for amyloidosis patient, it might be difficult to identify specific proteins from amyloid-deposited tissue. Apolipoprotein A-IV is known as an amyloid-associated protein, but there have been few reports of apolipoprotein A-IV amyloidosis. Here we report a case of systemic apolipoprotein A-IV-associated amyloidosis that was confirmed by proteome analysis using formalin-fixed paraffin-embedded tissue and an immunohistochemical technique.

Indexed as

ProteomeProteomicsAgedAmyloidosisApolipoproteins AAutopsyBiomarkersDisease ProgressionFatal OutcomeHumansImmunohistochemistryMaleParaffin EmbeddingPredictive Value of TestsTissue Fixationapolipoprotein A-IVApolipoproteins ABiomarkersProteomeAmyloidosisApolipoprotein A-IVFormalin-fixed paraffin-embedded tissueProteome analysis

Identifiers

PMID33751222
OpenAlexW3133654743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.