ArticleThe Plant cell2021
Mapping and engineering of auxin-induced plasma membrane dissociation in BRX family proteins.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- PAX-regulated self-organizing polarity drives procambial strand formation.Nature plants · 2026Article
- The brassinosteroid receptor geneScience advances · 2024Article
- Comprehensive identification and systematical characterization of BRX gene family and the functional of GhBRXL5A in response to salt stress.BMC plant biology · 2024Article
- Ectopic assembly of an auxin efflux control machinery shifts developmental trajectories.The Plant cell · 2024Article
- Article
- Asymmetric cell division in plant development.Journal of integrative plant biology · 2023Review
- A phosphoinositide hub connects CLE peptide signaling and polar auxin efflux regulation.Nature communications · 2023Article
- BRXL4-LAZY1 interaction at the plasma membrane controls Arabidopsis branch angle and gravitropism.The Plant journal : for cell and molecular biology · 2023Article
- Heterologous expression of a lycophyte protein enhances angiosperm seedling vigor.Development (Cambridge, England) · 2022Article
- Conserved signalling components coordinate epidermal patterning and cuticle deposition in barley.Nature communications · 2022Article
- Protein polarization: Spatiotemporal precisions in cell division and differentiation.Current opinion in plant biology · 2022Review
- Auxin Transporters-A Biochemical View.Cold Spring Harbor perspectives in biology · 2022Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiosperms have evolved the phloem for the long-distance transport of metabolites. The complex process of phloem development involves genes that only occur in vascular plant lineages. For example, in Arabidopsis thaliana, the BREVIS RADIX (BRX) gene is required for continuous root protophloem differentiation, together with PROTEIN KINASE ASSOCIATED WITH BRX (PAX). BRX and its BRX-LIKE (BRXL) homologs are composed of four highly conserved domains including the signature tandem BRX domains that are separated by variable spacers. Nevertheless, BRX family proteins have functionally diverged. For instance, BRXL2 can only partially replace BRX in the root protophloem. This divergence is reflected in physiologically relevant differences in protein behavior, such as auxin-induced plasma membrane dissociation of BRX, which is not observed for BRXL2. Here we dissected the differential functions of BRX family proteins using a set of amino acid substitutions and domain swaps. Our data suggest that the plasma membrane-associated tandem BRX domains are both necessary and sufficient to convey the biological outputs of BRX function and therefore constitute an important regulatory entity. Moreover, PAX target phosphosites in the linker between the two BRX domains mediate the auxin-induced plasma membrane dissociation. Engineering these sites into BRXL2 renders this modified protein auxin-responsive and thereby increases its biological activity in the root protophloem context.
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