ArticleThe Plant cell2021
Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Root colonization by beneficial rhizobacteria.FEMS microbiology reviews · 2024Pooled it
- Apoplast Engineering Unveiled: Multi-Target Strategies to Disarm Pathogens and Elevate Global Food Security.Plant, cell & environment · 2026Review
- Integrated physiological, element content, transcriptomic and weighted gene co-expression network analysis provide insights into the response mechanisms of Areca catechu to Zn/Fe deficiency stress.BMC plant biology · 2026Article
- Identification of Transcription Factors ofPlants (Basel, Switzerland) · 2025Article
- Autophagic regulation of ferroportin 1 induces developmental ferroptosis in rice blast.Autophagy · 2025Article
- A 'Candidatus Liberibacter asiaticus' effector SDE2470 facilitates citrus transcription factor CsVOZ2 degradation via BRUTUS E3 ligases.PLoS pathogens · 2025Article
- An RNA helicase coordinates with iron signal regulators to alleviate chilling stress in Arabidopsis.Nature communications · 2025Article
- Combating plant diseases through transition metal allocation.The New phytologist · 2025Review
- Novel Regulators and Their Epistatic Networks in Arabidopsis' Defence Responses to Alternaria alternata Infection.Molecular plant pathology · 2025Article
- Untangling iron threads: A deep dive into plant intracellular pools.Quantitative plant biology · 2025Review
- OsHRZ1 negatively regulates rice resistant to Magnaporthe oryzae infection by targeting OsVOZ2.Transgenic research · 2024Article
- The MYB transcription factor OsMYBxoc1 regulates resistance to Xoc by directly repressing transcription of the iron transport gene OsNRAMP5 in rice.Plant communications · 2024Article
- Extracellular niche establishment by plant pathogens.Nature reviews. Microbiology · 2024Review
- SreC-dependent adaption to host iron environments regulates the transition of trophic stages and developmental processes of Curvularia lunata.Molecular plant pathology · 2024Article
- Greater than the sum of their parts: an overview of the AvrRps4 effector family.Frontiers in plant science · 2024Review
- Article
- Article
- How plants manage pathogen infection.EMBO reports · 2024Review
- Microbiota and the plant immune system work together to defend against pathogens.Archives of microbiology · 2023Review
- The Role of Iron in Phytopathogenic Microbe-Plant Interactions: Insights into Virulence and Host Immune Response.Plants (Basel, Switzerland) · 2023Review
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
Acquisition of nutrients from different species is necessary for pathogen colonization. Iron is an essential mineral nutrient for nearly all organisms, but little is known about how pathogens manipulate plant hosts to acquire iron. Here, we report that AvrRps4, an effector protein delivered by Pseudomonas syringae bacteria to plants, interacts with and targets the plant iron sensor protein BRUTUS (BTS) to facilitate iron uptake and pathogen proliferation in Arabidopsis thaliana. Infection of rps4 and eds1 by P. syringae pv. tomato (Pst) DC3000 expressing AvrRps4 resulted in iron accumulation, especially in the plant apoplast. AvrRps4 alleviates BTS-mediated degradation of bHLH115 and ILR3(IAA-Leucine resistant 3), two iron regulatory proteins. In addition, BTS is important for accumulating immune proteins Enhanced Disease Susceptibility1 (EDS1) at both the transcriptional and protein levels upon Pst (avrRps4) infections. Our findings suggest that AvrRps4 targets BTS to facilitate iron accumulation and BTS contributes to RPS4/EDS1-mediated immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.