ArticleG3 (Bethesda, Md.)2021
Shannon entropy as a metric for conditional gene expression in Neurospora crassa.
Article in G3 (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Research on multi-trait genome association study method based on Shannon information entropy.BMC bioinformatics · 2026Article
- Combined generalist and host-specific transcriptional strategies enable host generalism in the fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tissue-Specific Chromatin Accessibility Regions and Transcription Factor Binding Sites in Pig Brain and Endocrine Tissues.Molecular neurobiology · 2025Article
- A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics.Pharmacology research & perspectives · 2025Review
- Quantification of transcript isoforms at the single-cell level using SCALPEL.Nature communications · 2025Article
- Review
- Ovarian cancer cells exhibit diverse migration strategies on stiff collagenous substrata.Biophysical journal · 2024Article
- Quantifying transcriptome diversity: a review.Briefings in functional genomics · 2024Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neurospora crassa has been an important model organism for molecular biology and genetics for over 60 years. Neurospora crassa has a complex life cycle, with over 28 distinct cell types and is capable of transcriptional responses to many environmental conditions including nutrient availability, temperature, and light. To quantify variation in N. crassa gene expression, we analyzed public expression data from 97 conditions and calculated the Shannon Entropy value for Neurospora's approximately 11,000 genes. Entropy values can be used to estimate the variability in expression for a single gene over a range of conditions and be used to classify individual genes as constitutive or condition-specific. Shannon entropy has previously been used measure the degree of tissue specificity of multicellular plant or animal genes. We use this metric here to measure variable gene expression in a microbe and provide this information as a resource for the N. crassa research community. Finally, we demonstrate the utility of this approach by using entropy values to identify genes with constitutive expression across a wide range of conditions and to identify genes that are activated exclusively during sexual development.
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Registered trials
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